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Human DKK1 Recombinant Protein LS-G105

Ordering

Wt. Vol. Conc. Price
2 µg - - $215
10 µg - - $285
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular DKK1 Proteins

Human DKK1 Recombinant (His) Protein - LS-G19257
E. coli Expression System
His
Unpurified / Lyophilized
DKK1 Recombinant Protein - LS-G27007
Hamster-Chinese CHO Cells
None
Unpurified / Endotoxin Level: Less than 0.2 EU/µg protein (determined by LAL method).
Human DKK1 Recombinant Protein - LS-G27268
Hamster-Chinese CHO Cells
None
Unpurified / Endotoxin Level: Less than 0.2 EU/µg protein (determined by LAL method).

100% Guaranteed 100% Guaranteed
LS-G105
Recombinant Protein
DKK1
Human
35-40 kDa
TLNSVLNSNA IKNLPPPLGG AAGHPGSAVS AAPGILYPGG
NKYQTIDNYQ PYPCAEDEEC GTDEYCASPT RGGDAGVQIC
LACRKRRKRC MRHAMCCPGN YCKNGICVSS DQNHFRGEIE
ETITESFGND HSTLDGYSRR TTLSSKMYHT KGQEGSVCLR
SSDCASGLCC ARHFWSKICK PVLKEGQVCT KHRRKGSHGL
EIFQRCYCGE GLSCRIQKDH HQASNSSRLH TCQRH
HEK 293 Cells
Human
None
Greater than 97% by SDS-PAGE and HPLC
Determined by its ability to inhibit the proliferation of HCT116 colorectal carcinoma cells. Approximately 40% growth inhibition was achieved at a DKK-1 concentration of 200ng/ml.
Less than 0.1 ng/µg of protein (less than 1EU/µg).
Sterile filtered, lyophilized from 1X PBS, pH 7.4
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
If lyophilized, can be stored for 1 month at room temperature, 6 months at 4°C, or through the expiration date at -20°C to -80°C. Once reconstituted per the supplied instructions, can be stored for 3 months at -20°C to -80°C, or for 1 week at 2°C to 8°C. Avoid repeat freeze-thaw cycles.
For research use only.

About DKK1

O94907 NM_012242 NP_036374.1

DKK1 Protein, Dickkopf-1 like Protein, DKK-1 Protein, Dickkopf-1 Protein, Dickkopf-related protein 1 Protein, Dickkopf related protein-1 Protein, HDkk-1 Protein, Hdkk1 Protein, Dickkopf-like protein 1 Protein, SK Protein

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Requested From: United States
Date Requested: 12/3/2016

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