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Human CNTF Protein (Recombinant) - LS-G27102

Catalog Size Price
LS-G27102-10 10 µg Unavailable
LS-G27102-50 50 µg Unavailable
LS-G27102-1 1 mg Unavailable

Most Popular CNTF Proteins

Human CNTF Protein (Recombinant) - LS-G446
E. coli Expression System
199 AA
None
Purified / Lyophilized / Biologically Active / Endotoxin Level: Less than 0.1 ng/µg of protein (less than 1EU/µg).
Rat CNTF Protein (Recombinant) - LS-G477
E. coli Expression System
199 AA
None
Purified / Lyophilized / Biologically Active / Endotoxin Level: Less than 0.1 ng/µg of protein (less than 1EU/µg).
Human CNTF Protein (Recombinant) - LS-G1380
E. coli Expression System
200 AA
None
Purified
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Human CNTF Protein (Recombinant His) - LS-G3372
E. coli Expression System
220 AA
His
Purified
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Human CNTF Protein (Recombinant) - LS-G3619
E. coli Expression System
199 AA
None
Purified / Lyophilized / Biologically Active / Animal-Free / Endotoxin Level: Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).

100% Guaranteed
LS-G27102
Recombinant Protein
CNTF
Human
22.8 kDa (SDS-PAGE)
Ciliary Neurotrophic Factor (CNTF) is a cytokine belonging to the Interleukin 6 (IL-6) family, which also includes IL-6, Oncostatin M, Leukemia Inhibitory Factor (LIF), and Cardiotrophin-1. Structurally, CNTF resembles a four-helix bundle composition, similar to the other members of the IL-6 family. The receptor for CNTF is composed of three parts: a gp130-like subunit common in the IL-6 receptor family, a LIF Receptor ß subunit, and a CNTF specific a receptor subunit. Upon binding to the CNTF, the ß subunit of the CNTF receptor will undergo tyrosine phosphorylation, and activate the intracellular JAK/STAT pathway. The main function of CNTF in vivo is to promote the differentiation and survival of a variety of neurons and glial cells, including sympathetic precursor cells and spinal motor neurons.Recombinant human Ciliary Neurotrophic Factor (rhCNTF) produced in E. coli is a single non-glycosylated polypeptide chain containing 199 amino acids. A fully biologically active molecule, rhCNTF has a molecular mass of 22.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques.
AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTESYVKH
QGLNKNINLD SADGMPVAST DQWSELTEAE RLQENLQAYR
TFHVLLARLL EDQQVHFTPT EGDFHQAIHT LLLQVAAFAY
QIEELMILLE YKIPRNEADG MPINVGDGGL FEKKLWGLKV
LQELSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM
E. coli
E. coli
None
Greater than 95% by SDS-PAGE and HPLC
ED50 < 200 ng/ml, measured cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 5x103 units/mg.
Less than 0.2 EU/µg protein (determined by LAL method).
Lyophilized from PBS.
Stable at -80°c for up to 6 months. Upon reconstitution, store at 4°c for up to 2 weeks or at -20°c for up to 3 months.
For research use only.

About CNTF

P26441 NM_000614 NP_000605.1

CNTF Protein, Ciliary neurotrophic factor Protein, HCNTF Protein

CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks.

Requested From: 
Date Requested: 5/25/2018

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