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Human CDK4 Recombinant (6His + T7,N-terminus) Protein (Met1-Glu303) - LS-G39631

Ordering

Wt. Vol. Conc. Price
10 µg - - Unavailable
50 µg - - Unavailable
500 µg - - Unavailable
1000 µg - - Unavailable

Most Popular CDK4 Proteins

Human CDK4 Recombinant (His) Protein - LS-G1946
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Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image
Mouse CDK4 Recombinant (His) Protein (aa26-137) - LS-G13522
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Human CDK4 Recombinant (His) Protein (aa6-295) - LS-G13523
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Human CDK4 Recombinant (His) Protein (Full Length) - LS-G22551
E. coli Expression System
302 AA
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100% Guaranteed 100% Guaranteed
LS-G39631
Recombinant Protein
CDK4
Human
37.2kD
Recombinant Human Cyclin-Dependent Kinase 4 is produced by our E. coli expression system and the target gene encoding Met1-Glu303 is expressed with a 6His, T7 tag at the N-terminus.
Met1-Glu303
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSMATSRY
EPVAEIGVGA YGTVYKARDP HSGHFVALKS VRVPNGGGGG
GGLPISTVRE VALLRRLEAF EHPNVVRLMD VCATSRTDRE
IKVTLVFEHV DQDLRTYLDK APPPGLPAET IKDLMRQFLR
GLDFLHANCI VHRDLKPENI LVTSGGTVKL ADFGLARIYS
YQMALTPVVV TLWYRAPEVL LQSTYATPVD MWSVGCIFAE
MFRRKPLFCG NSEADQLGKI FDLIGLPPED DWPRDVSLPR
GAFPPRGPRP VQSVVPEMEE SGAQLLLEML TFNPHKRISA
FRALQHSYLH KDEGNPE
E. coli
E. coli
6His + T7,N-terminus
Greater than 95% by SDS-PAGE
Less than 0.1 EU/µg protein (determined by LAL method).
Lyophilized
Lyophilized protein should be stored at < -20°C. Reconstituted protein solution can be stored at 4-7°C for 2-7 days.Aliquots of reconstituted samples are stable at < -20°C for 3 months.
For research use only.

About CDK4

P11802 NM_000075 NP_000066.1

CDK4 Protein, Cell division protein kinase 4 Protein, Crk3 Protein, Cyclin-dependent kinase 4 Protein, CMM3 Protein, p34/cdk4 Protein, PSK-J3 Protein

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase.

Requested From: 
Date Requested: 4/25/2017

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