Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Measured by its binding ability in a functional ELISA.Immobilized Cynomolgus IL1R2-Fc at 10 µg/ml (100 µl/well) can bind biotinylated human IL1B-His, The EC50 of biotinylated human IL1B-His is 11.8-27.4 ng/ml.
Lyophilized PBS, pH 7.4
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
IL1R2 Protein, CD121b Protein, CD121b antigen Protein, CDw121b Protein, IL-1RT-2 Protein, IL1R2c Protein, Interleukin-1 receptor beta Protein, Interleukin-1 receptor type II Protein, IL-1R-beta Protein, Antigen CDw121b Protein, IL-1 type II receptor Protein, IL-1R-2 Protein, IL-1RT2 Protein, IL1RB Protein, Interleukin-1 receptor type 2 Protein
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN.