Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Purified / Lyophilized / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
CD121b / IL1R2
Greater than 95% by SDS-PAGE
Measured by its binding ability in a functional ELISA.Immobilized mouse IL1R2-His at 10 µg/ml (100 µl/well) can bind biotinylated human IL1B-His, The EC50 of biotinylated human IL1B-His is 0.37-0.85 µg/ml.
Less than 1.0 EU/µg protein (determined by LAL method).
Lyophilized from sterile PBS, pH 7.4
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
IL1R2 Protein, CD121b Protein, CD121b antigen Protein, CDw121b Protein, IL-1RT-2 Protein, IL1R2c Protein, Interleukin-1 receptor beta Protein, Interleukin-1 receptor type II Protein, IL-1R-beta Protein, Antigen CDw121b Protein, IL-1 type II receptor Protein, IL-1R-2 Protein, IL-1RT2 Protein, IL1RB Protein, Interleukin-1 receptor type 2 Protein
Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN.