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| Catalog Number | Size | Price |
|---|---|---|
| LS-G3944-10 | 10 µg | $386 |
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Human BAFF / TNFSF13B Protein (Recombinant His) (aa134-285) - LS-G3944
Human BAFF / TNFSF13B Protein (Recombinant His) (aa134-285) - LS-G3944
Description:
BAFF / TNFSF13B Protein LS-G3944 is a Recombinant Human BAFF / TNFSF13B produced in E. coli aa 134-285 with His tag(s). It is low in endotoxin; Less than 0.01 EU/µg protein (determined by LAL method). For Research Use Only
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Description:
BAFF / TNFSF13B Protein LS-G3944 is a Recombinant Human BAFF / TNFSF13B produced in E. coli aa 134-285 with His tag(s). It is low in endotoxin; Less than 0.01 EU/µg protein (determined by LAL method). For Research Use Only
Specifications
Type
Recombinant Protein
Target
BAFF / TNFSF13B
Synonyms
TNFSF13B | B-cell-activating factor | BAFF | ApoL related ligand TALL-1 | B-lymphocyte stimulator | CD257 | BLYS | Delta4 BAFF | Delta BAFF | TALL-1 | TALL1 | ZTNF4 | THANK | B lymphocyte stimulator | CD257 antigen | TNFSF20
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Tag
His
Region
aa 134-285
Predicted Molecular Weight
~19kDa (under reduced conditions)~1100kDa (under native conditions)
Expression System
E. coli
Source Species
E. coli
Purification
Greater than 95% by SDS-PAGE
Bio-Activity
Increases B cell survival/proliferation. Increases CD21/CD23 expression on B cells in vivo. Activates BAFF-R, TACI and BCMA receptors. Works at concentrations <20ng/ml.
Endotoxin
Less than 0.01 EU/µg protein (determined by LAL method).
Presentation
Lyophilized from PBS
Reconstitution
Reconstitute with 100 µl sterile water.
Storage
Store lyophilized at -20°C for up to 6 months. Once reconstituted store at 4°C for immediate use.
Restrictions
For research use only. Intended for use by laboratory professionals.
About BAFF / TNFSF13B
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Images
Functional Assay
Coomassie blue staining of BAFF, Soluble (human) (60-mer) (AG-40B-0112) under reducing conditions (shows the size of the monomer).
Functional Assay
Size fractionation on Superdex-200. A. BAFF (60-mer) was submitted to size fractionation on a Superdex 200 gel filtration column. The peak indicated with dotted red lines (60-mer) was isolated and processed to obtain purified BAFF, Soluble (human) (60-mer) (AG-40B-0112). Elution position of MW markers are indicated on the top of the figure. B. For comparison, elution profile of the related product BAFF, Soluble (human) (3-mer).
Functional Assay
BAFF, Soluble (human) (60-mer) (AG-40B-0112) binds and activates BCMA receptor. Method: Jurkat T cells expressing a BCMA:Fas chimerical receptor (containing a extracellular domain of human BCMA and the intracellular domain of human Fas) were exposed for 16h to various concentrations of BAFF, Soluble (human) (60-mer). Cell viability was measured with the PMS/MTS assay.
Functional Assay
Coomassie blue staining of BAFF, Soluble (human) (60-mer) (AG-40B-0112) under reducing conditions (shows the size of the monomer).
Functional Assay
Size fractionation on Superdex-200. A. BAFF (60-mer) was submitted to size fractionation on a Superdex 200 gel filtration column. The peak indicated with dotted red lines (60-mer) was isolated and processed to obtain purified BAFF, Soluble (human) (60-mer) (AG-40B-0112). Elution position of MW markers are indicated on the top of the figure. B. For comparison, elution profile of the related product BAFF, Soluble (human) (3-mer).
Functional Assay
BAFF, Soluble (human) (60-mer) (AG-40B-0112) binds and activates BCMA receptor. Method: Jurkat T cells expressing a BCMA:Fas chimerical receptor (containing a extracellular domain of human BCMA and the intracellular domain of human Fas) were exposed for 16h to various concentrations of BAFF, Soluble (human) (60-mer). Cell viability was measured with the PMS/MTS assay.
Functional Assay
Coomassie blue staining of BAFF, Soluble (human) (60-mer) (AG-40B-0112) under reducing conditions (shows the size of the monomer).
Functional Assay
Size fractionation on Superdex-200. A. BAFF (60-mer) was submitted to size fractionation on a Superdex 200 gel filtration column. The peak indicated with dotted red lines (60-mer) was isolated and processed to obtain purified BAFF, Soluble (human) (60-mer) (AG-40B-0112). Elution position of MW markers are indicated on the top of the figure. B. For comparison, elution profile of the related product BAFF, Soluble (human) (3-mer).
Functional Assay
BAFF, Soluble (human) (60-mer) (AG-40B-0112) binds and activates BCMA receptor. Method: Jurkat T cells expressing a BCMA:Fas chimerical receptor (containing a extracellular domain of human BCMA and the intracellular domain of human Fas) were exposed for 16h to various concentrations of BAFF, Soluble (human) (60-mer). Cell viability was measured with the PMS/MTS assay.
Functional Assay
Coomassie blue staining of BAFF, Soluble (human) (60-mer) (AG-40B-0112) under reducing conditions (shows the size of the monomer).
Functional Assay
Size fractionation on Superdex-200. A. BAFF (60-mer) was submitted to size fractionation on a Superdex 200 gel filtration column. The peak indicated with dotted red lines (60-mer) was isolated and processed to obtain purified BAFF, Soluble (human) (60-mer) (AG-40B-0112). Elution position of MW markers are indicated on the top of the figure. B. For comparison, elution profile of the related product BAFF, Soluble (human) (3-mer).
Functional Assay
BAFF, Soluble (human) (60-mer) (AG-40B-0112) binds and activates BCMA receptor. Method: Jurkat T cells expressing a BCMA:Fas chimerical receptor (containing a extracellular domain of human BCMA and the intracellular domain of human Fas) were exposed for 16h to various concentrations of BAFF, Soluble (human) (60-mer). Cell viability was measured with the PMS/MTS assay.
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/24/2024
Date Requested: 4/24/2024
