Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase).
Coomassie blue staining of BAFF, Soluble (human) (60-mer) (AG-40B-0112) under reducing conditions (shows the size of the monomer).
Size fractionation on Superdex-200. A. BAFF (60-mer) was submitted to size fractionation on a Superdex 200 gel filtration column. The peak indicated with dotted red lines (60-mer) was isolated and processed to obtain purified BAFF, Soluble (human) (60-mer) (AG-40B-0112). Elution position of MW markers are indicated on the top of the figure. B. For comparison, elution profile of the related product BAFF, Soluble (human) (3-mer).
BAFF, Soluble (human) (60-mer) (AG-40B-0112) binds and activates BCMA receptor. Method: Jurkat T cells expressing a BCMA:Fas chimerical receptor (containing a extracellular domain of human BCMA and the intracellular domain of human Fas) were exposed for 16h to various concentrations of BAFF, Soluble (human) (60-mer). Cell viability was measured with the PMS/MTS assay.