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Human BAFF Recombinant (His) Protein LS-G3944

Ordering

Wt. Vol. Conc. Price
10 µg - - $315
Inquire for larger quantities
LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular BAFF Proteins

Human BAFF Recombinant Protein - LS-G4434
E. coli Expression System
None
Unpurified / Endotoxin Level: Less than 0.1 ng/µg of protein.
Rat BAFF Recombinant Protein - LS-G4440
E. coli Expression System
None
Unpurified / Endotoxin Level: Less than 0.1 ng/µg of protein.
Human BAFF Recombinant Protein - LS-G16806
E. coli Expression System
None
Unpurified

100% Guaranteed 100% Guaranteed
LS-G3944
Recombinant Protein
BAFF
Human
~19kDa (under reduced conditions)~1100kDa (under native conditions)
The extracellular domain of human BAFF (aa 134-285) is fused at the N-terminus to a His-tag.
aa 134-285
E. coli
E. coli
His
Greater than 95% by SDS-PAGE
Increases B cell survival/proliferation. Increases CD21/CD23 expression on B cells in vivo. Activates BAFF-R, TACI and BCMA receptors. Works at concentrations <20ng/ml.
Less than 0.01 EU/µg protein (determined by LAL method).
Lyophilized from PBS.
Reconstitute with 100 µl sterile water.
Store lyophilized at -20°C for at least 6 months. Once reconstituted store at +4°C for immediate use.
For research use only.

About BAFF

Q9Y275 NM_006573 NP_006564.1

TNFSF13B Protein, B-cell-activating factor Protein, BAFF Protein, ApoL related ligand TALL-1 Protein, B-lymphocyte stimulator Protein, CD257 Protein, BLYS Protein, Delta4 BAFF Protein, Delta BAFF Protein, TALL-1 Protein, TALL1 Protein, ZTNF4 Protein, THANK Protein, B lymphocyte stimulator Protein, CD257 antigen Protein, TNFSF20 Protein

Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF (for B cell Activating Factor belonging to the TNF Family), BLyS (for B Lymphocyte Stimulator), TALL-1 (for TNF- and ApoL-related Leukocyte-expressed Ligand), and THANK (for TNF Homologue that Activate Apoptosis, NF-kB and c-jun N-terminal Kinase).

Functional Assay

Functional Assay
Coomassie blue staining of BAFF, Soluble (human) (60-mer) (AG-40B-0112) under reducing conditions (shows the size of the monomer).

Functional Assay

Functional Assay
Size fractionation on Superdex-200. A. BAFF (60-mer) was submitted to size fractionation on a Superdex 200 gel filtration column. The peak indicated with dotted red lines (60-mer) was isolated and processed to obtain purified BAFF, Soluble (human) (60-mer) (AG-40B-0112). Elution position of MW markers are indicated on the top of the figure. B. For comparison, elution profile of the related product BAFF, Soluble (human) (3-mer).

Functional Assay

Functional Assay
BAFF, Soluble (human) (60-mer) (AG-40B-0112) binds and activates BCMA receptor. Method: Jurkat T cells expressing a BCMA:Fas chimerical receptor (containing a extracellular domain of human BCMA and the intracellular domain of human Fas) were exposed for 16h to various concentrations of BAFF, Soluble (human) (60-mer). Cell viability was measured with the PMS/MTS assay.
 

Requested From: United States
Date Requested: 12/2/2016

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