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Proteins > BAFF / TNFSF13B > LS-G3957
 
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Catalog Number Size Price
LS-G3957-10 10 µg $344 
BAFF / TNFSF13B Protein - Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).

Human BAFF / TNFSF13B Protein (Recombinant Human IgG1 Fc) (aa136-285) - LS-G3957

Human BAFF / TNFSF13B Protein (Recombinant Human IgG1 Fc) (aa136-285) - LS-G3957

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Description:
BAFF / TNFSF13B Protein LS-G3957 is a Recombinant Human BAFF / TNFSF13B produced in CHO Cells aa 136-285 with Human IgG1 Fc tag(s). It is low in endotoxin; Less than 0.01 EU/µg protein (determined by LAL method). For Research Use Only
Price
Catalog Number
$344
LS-G3957-10
Toll Free North America
206-374-1102
For Research Use Only
Specifications Publications Reviews Images Request SDS/MSDS

Overview

Description:
BAFF / TNFSF13B Protein LS-G3957 is a Recombinant Human BAFF / TNFSF13B produced in CHO Cells aa 136-285 with Human IgG1 Fc tag(s). It is low in endotoxin; Less than 0.01 EU/µg protein (determined by LAL method). For Research Use Only

Specifications

Type
Recombinant Protein
Target
BAFF / TNFSF13B
Synonyms
TNFSF13B | B-cell-activating factor | BAFF | ApoL related ligand TALL-1 | B-lymphocyte stimulator | CD257 | BLYS | Delta4 BAFF | Delta BAFF | TALL-1 | TALL1 | ZTNF4 | THANK | B lymphocyte stimulator | CD257 antigen | TNFSF20
Species
Human
Modifications
Unmodified
Conjugations
Unconjugated
Tag
Human IgG1 Fc
Region
aa 136-285
Predicted Molecular Weight
50kDa or 100kDa or 300kDa
Expression System
CHO Cells
Source Species
Hamster-Chinese
Purification
Greater than 95% by SDS-PAGE
Bio-Activity
Rescues the production of mature follicular and marginal zone B cells.-in vitro: Addition of 1-100 ng/ml of Fc-BAFF induces B cell survival in a dose-dependent manner.-in vivo: Fc-BAFF treatment rescues mature B cell development in BAFF deficient mice.
Endotoxin
Less than 0.01 EU/µg protein (determined by LAL method).
Presentation
Lyophilized from PBS
Reconstitution
Reconstitute with 100 µl sterile water.
Storage
Store lyophilized at -20°C for up to 6 months. Once reconstituted store at 4°C for immediate use.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This protein carries the LSBio 100% Guarantee.
LSBio Guarantee
About BAFF / TNFSF13B
Q9Y275 NM_006573 NP_006564.1

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Images

Functional Assay

BAFF / TNFSF13B Protein - Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).
Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).

Functional Assay

BAFF / TNFSF13B Protein - Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).
Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).

Functional Assay

BAFF / TNFSF13B Protein - Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).
Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).

Functional Assay

BAFF / TNFSF13B Protein - Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).
Restoration of the splenic T and B cell architecture in Fc-BAFF injected BAFFdeficient mice. BAFF deficient mice were injected at day 0 with 100mg BAFF (human):Fc (human) (AG-40B-0120) intravenously and at day 14 with 50mg BAFF (human):Fc (human) intraperitoneal. At day 21, injected BAFFdeficient mice were sacrificed together with WT and control BAFFdeficient mice and splenic T and B cell architecture was analyzed by fluorescence microscopy on cryosections. A, Spleen sections of WT (left picture), BAFF deficient (middle picture) or injected BAFFdeficient mice (right picture) were stained for IgM (red) and CD90 (green). (B) Spleen sections of the same mice were stained for IgM (green) and MOMA (red).

Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/23/2024
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