Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
AGA Protein, AGU Protein, Aspartylglucosaminidase Protein, ASRG Protein, GA Protein, Glycosylasparaginase Protein
Glycosylasparaginase (AGA), a Threonine T1 protease, is a lysosomal enzyme that hydrolyzes N-linked oligosaccharides of glycoproteins. Inactivating mutations of AGA cause massive accumulation of aspartylglucosamine and lysosomal hypertrophy in the central nervous system, leading to Aspartylglycosaminuria (AGU). AGU is an autosomal recessive disease, characterized by decreased cognitive abilities, skeletal abnormalities, and facial grotesqueness (Aronson NN Jr., 1999).