Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
ADIPOQ Protein, Adiponectin Protein, ADPN Protein, ACDC Protein, ADIPQTL1 Protein, APM-1 Protein, APM1 Protein, ACRP30 Protein, Gelatin-binding protein 28 Protein, GBP28 Protein, Gelatin-binding protein Protein
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects.
Effect of Adiponectin (human) (rec.) (His) on the phosphorylation of acetyl-CoA carboxylase (ACC) in C2C12 cells. C2C12 myocytes were treated with 25 ug/ml for 15 minutes after serum starvation for 24 hours. 100 ug per well of total cell lysate was separated on reduced SDS-PAGE gels. Immunoblot analysis was performed to measure phosphorylation of ACC with an anti-phosphoACC antibody. 1: 25 ug/ml of Adiponectin (human) (rec.) (His). 2: 25 ug/ml of a His-tagged control protein. 3: phosphate-buffered saline.