Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Lyophilized / Biologically Active / Endotoxin Level: Less than 1.0 EU/µg protein (determined by LAL method).
Ser 110-Ser 263
Greater than 97% by SDS-PAGE
1. Measured by its binding ability in a functional ELISA. Immobilized Canine IL33 at 10 µg/ml (100 µl/well) can bind human IL1R4-Fc, The EC50 of human IL1R4-Fc is 0.25-0.66 µg/ml. 2. Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells costimulated with anti-CD 2. The ED50 for this effect is typically 10-40 ng/mL.
Lyophilized from sterile 5 mM EDTA, PBS, pH 7.5.
Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
IL33 Protein, C9orf26 Protein, DVS27 Protein, DVS27-related protein Protein, IL-1F11 Protein, IL-33 Protein, Interleukin-33 Protein, NFEHEV Protein, NF-HEV Protein, Interleukin-1 family member 11 Protein, NFHEV Protein, IL1F11 Protein, Interleukin 33 Protein, RP11-575C20.2 Protein
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells.