Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
1. Measured by its ability to bind human IGFBP4-His in a functional ELISA. 2. Measured by its ability to bind mouse IGFBP4-His in a functional ELISA. 2. Measured by its ability to bind Cynomolgus IGFBP1-His in a functional ELISA.4. Measured by its ability to bind human IGF1R (aa 954-1367)-GST in a functional ELISA.5. Measured in a serum-free cell proliferation assay using MCF-7 human breast cancer cells. The ED50 for this effect is typically 0.5-2 ng/mL.6. Measured in a cell proliferation assay
Lyophilized from 30% Acetonitrile, 0.1% TFA.
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts.