Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Measured by its binding ability in a functional ELISA. Immobilized human BCL2-His at 10 µg/ml (100 µl/well) can bind biotinylated mouse BCL2L1-His, The EC50 of biotinylated mouse BCL2L1-His is 0.07-0.15 µg/ml.
Lyophilized from sterile 50 mM Tris, 20% glycerol, 100 mM Arginine, pH 8.5.
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
BCL2 Protein, Apoptosis regulator Bcl-2 Protein, B-cell CLL/lymphoma 2 Protein, B-cell lymphoma protein 2 Protein, Bcl-2 Protein, PPP1R50 Protein
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).