Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
1. The specific activity was determined to be 166 nmol/min/mg using poly [Glu, Tyr] 4:1 as substrate. 2. Measured by its binding ability in a functional ELISA. Immobilized recombinant Mouse SRC at 2 µg/ml (100 µl/well) can bind biotinylated human PTPRA (aa 174-793) with a linear range of 0.032-0.8 µg/ml.
Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.01.
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors.