Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
1. The specific activity was determined to be 9168 nmol/min/mg using p-nitrophenyl phosphate as substrate. 2. Measured by its binding ability in a functional ELISA. Immobilized mouse PTPRC (453-1152) at 10 µg/ml (100 µl/well) can bind biotinylated human Galectin-1 with a linear range of 0.31-2.5 µg/ml.
Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, 3 mM DTT, ph 7.4.
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
PTPRC Protein, B220 Protein, CD45R Protein, CD45 Protein, gp180 Protein, Leukocyte common antigen Protein, L-CA Protein, Leucocyte common antigen Protein, LY5 Protein, T200 Protein, T200 glycoprotein Protein, T200 leukocyte common antigen Protein, CD45 antigen Protein, LCA Protein
CD45 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP.