Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
1. The specific activity was determined to be 10 nmol/min/mg using MBP as substrate. 2. Measured by its binding ability in a functional ELISA. Immobilized human HGFR (aa 956-1390) at 10 µg/ml (100 µl/well) can bind biotinylated human HGF-his with a linear range of 15.6-125 ng/ml.
Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10% glycerol, 3 mM DTT.
Aliquot and store at -20°C or -80°C. Avoid freeze-thaw cycles.
MET Protein, AUTS9 Protein, C-Met Protein, HGF/SF receptor Protein, HGFR Protein, Met kinase Protein, Proto-oncogene c-Met Protein, Scatter factor receptor Protein, SF receptor Protein, HGF receptor Protein, RCCP2 Protein, Tyrosine-protein kinase Met Protein
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.