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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
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866-819-4732 (Toll Free North America
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PathPlusTM CALCR / Calcitonin Receptor Antibodies
Calcitonin receptor (CALCR) is a transmembrane G-protein coupled protein that is a high-affinity receptor for calcitonin. It is involved in maintaining calcium homeostasis and regulating osteoclast-mediated bone resorption. This receptor is expressed during development and is involved in morphogenesis. In addition to binding calcitonin, CALCR can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. Polymorphisms in the gene are associated with susceptibility to osteoporosis, and different alternatively spliced protein isoforms may regulate biologic responses to calcitonin. Furthermore, loss of functional CALCR through somatic mutation in glioblastoma is associated with an aggressive phenotype and poor prognosis. In immunohistochemistry, CALCR has membranous positivity on neurons in the hypothalamus, in renal tubules, osteoclasts, the testis and kidney. References: J Clin Invest. 1992;90(5):1726-1735. doi: 10.1172/JCI116046; J Clin Invest. 1995;95(6):2680-2691. doi: 10.1172/JCI117970; Clin Cases Miner Bone Metab. 2007;4(2):117-122. PMID: 22461211; vMol Cell Proteomics. 2014;13(2):397-406. doi: 10.1074/mcp.M113.035600; The Journal of Cell Biology. 2004. 164 (4): 509–14, PMID: 14970190; Clin Cancer Res. 2018 Mar 15;24(6):1448-1458, PMID: 29263181;

3 PathPlusTM Antibodies

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CALCR / Calcitonin Receptor Antibody - Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
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Rabbit Polyclonal to Human CALCR / Calcitonin Receptor
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$425
CALCR / Calcitonin Receptor Antibody - Anti-Calcitonin Receptor antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
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Rabbit Polyclonal to Human CALCR / Calcitonin Receptor
Human
IHC, IHC-P
Unconjugated
50 µg/$425
CALCR / Calcitonin Receptor Antibody - Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Cancer
Fast Shipping
Rabbit Polyclonal to Human CALCR / Calcitonin Receptor
Human
IHC, IHC-P
Unconjugated
50 µg/$425
Viewing 1-3 of 3 products