Products
Services
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Catalog Number Size Price
LS-B2473-250 250 µl (0.2 mg/ml) $485 
Tyrosinase Antibody - Anti-Tyrosinase antibody IHC of human skin, melanocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

PathPlus™ Monoclonal Mouse anti‑Human Tyrosinase Antibody (clone T311, IHC, IF, WB) LS‑B2473

PathPlus™ Monoclonal Mouse anti‑Human Tyrosinase Antibody (clone T311, IHC, IF, WB) LS‑B2473

Note: This antibody replaces LS-C18403
Antibody:
Mouse Monoclonal to Human Tyrosinase
Application:
IHC, IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Cat, Dog
Format:
Unconjugated, Unmodified
Price
Catalog Number
$485 
LS-B2473-250
250 µl
0.2 mg/ml
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Mouse Monoclonal to Human Tyrosinase
Application:
IHC, IHC-P, ICC, IF, WB, ELISA
Reactivity:
Human, Cat, Dog
Format:
Unconjugated, Unmodified

Specifications

Description
Tyrosinase (TYR) is an enzyme that catalyzes steps in the conversion of tyrosine to melanin. Mutations in TYR results in oculocutaneous albinism, and polymorphisms results in variations in skin pigmentation. The protein is found in melanocytes in the skin and retina, and is useful to identify melanocytic neoplasms such as melanomas. It is also found in subsets of renal angiomyolipomas and PEComas. References: PNAS USA 1995 92:8125; Arch Path Lab Med 2007 131(1):122; Arch Path Lab Med 2009 133:648
Target
Human Tyrosinase
Synonyms
TYR | CMM8 | LB24-AB | SHEP3 | SK29-AB | Monophenol monooxygenase | Tumor rejection antigen AB | OCA1A | Tyrosinase | OCAIA
Host
Mouse
Reactivity
Human, Cat, Dog (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Clone
T311
Conjugations
Unconjugated
Purification
Protein A purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • ICC
  • Immunofluorescence
  • Western blot (1 - 2 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Recombinant tyrosinase protein. Epitope: 1-433.
Specificity
Recognizes a cluster of proteins between 70-80kD, identified as human tyrosinase. Occasionally a minor band at 55kD is also detected. Does not cross-react with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Species cross-reactivity: canine and feline. Weak cross-reactivity with mouse.
Usage
Immunohistochemistry: LS-B2473 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2473 was determined to be 10 ug/ml.
Presentation
PBS, pH 7.4, 0.09% Sodium Azide, 0.2% BSA
Storage
Short term: 4°C Long term: Aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About Tyrosinase
P14679 NM_000372 NP_000363.1

Validation

Tyrosinase Antibody - Anti-Tyrosinase antibody IHC of human skin, melanocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-Tyrosinase antibody IHC of human skin, melanocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-Tyrosinase antibody IHC of human skin, melanocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

LSBio Ratings

PathPlus™ Tyrosinase Antibody (clone T311) for IHC, ICC, IF/Immunofluorescence, WB/Western, ELISA LS-B2473 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 7/12/2020