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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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Catalog Number Size Price
LS-B12784-50 50 µl (1 mg/ml) $425 
PDCD1 / CD279 / PD-1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
PDCD1 / CD279 / PD-1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
PDCD1 / CD279 / PD-1 Antibody - Flow cytometric analysis of stable expression PD1 cells using anti-PDCD1 antibody (Red) compared to a nonspecific negative control antibody (Blue).(1:100)(1:50)
PDCD1 / CD279 / PD-1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
PDCD1 / CD279 / PD-1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
PDCD1 / CD279 / PD-1 Antibody - Flow cytometric analysis of stable expression PD1 cells using anti-PDCD1 antibody (Red) compared to a nonspecific negative control antibody (Blue).(1:100)(1:50)
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PathPlus™ PDCD1 / CD279 / PD‑1 Antibody Monoclonal Flo,IHC LS‑B12784

PathPlus™ PDCD1 / CD279 / PD‑1 Antibody Monoclonal Flo,IHC LS‑B12784

Note: This antibody replaces LS-C340097
Antibody:
Mouse Monoclonal to Human PDCD1 / CD279 / PD-1
Application:
IHC, IHC-P, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B12784-50
50 µl
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Mouse Monoclonal to Human PDCD1 / CD279 / PD-1
Application:
IHC, IHC-P, Flo
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
PD1 (Programmed Death Receptor 1, PDCD1, CD279) is an immune checkpoint protein active in T cells that is a target alongside its ligand PDL1 and also CTLA-4 for immunotherapy in lung and other cancers. PD1 is involved in negatively regulating T cell inflammatory activity and, when bound to receptors on tumor cells, can work to subdue tumor suppression by inhibiting the immune response. Targeted inhibition of PD1 itself can therefore function as an anti-cancer therapy by reactivating this response. PD1 is expected to have membranous staining in germinal center associated helper T cells, CD8+ T cells, and Pro-B cells. It is for the identification of subsets of T and B cell lymphomas and nodular lymphocyte predominant Hodgkin lymphomas. Alsaab, 2017; Jin, 2011; Francisco, 2010; Fife, 2011; Human Pathol 2008 39(7):1050
Target
Human PDCD1 / CD279 / PD-1
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2a Monoclonal
Clone
3C6
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (10 - 20 µg/ml)
  • Flow Cytometry (1:50)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Full length human recombinant protein of human PDCD1 (NP_005009) produced in HEK293T cell.
Specificity
Human PDCD1 / CD279 / PD-1
Presentation
PBS, pH 7.3, 0.02% Sodium Azide, 50% Glycerol, 1% BSA
Storage
Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About PDCD1 / CD279 / PD-1
Q15116 NM_005018 NP_005009.2

Validation

PDCD1 / CD279 / PD-1 Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

PDCD1 / CD279 / PD-1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

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Requested From: United States
Date Requested: 1/19/2020