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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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PathPlus™ CLDN1 / Claudin 1 Antibody aa162‑211 Polyclonal IHC,Peptide‑ELISA,WB LS‑B6327

Catalog Number Size Price
LS-B6327-100 100 µl (1 mg/ml) $254 
Anti-CLDN1 / Claudin 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Western blot analysis of lysates from HeLa cells, using Claudin 1 Antibody. The lane on the right is blocked with the synthesized peptide.
Anti-CLDN1 / Claudin 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Western blot analysis of lysates from HeLa cells, using Claudin 1 Antibody. The lane on the right is blocked with the synthesized peptide.
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PathPlus™ CLDN1 / Claudin 1 Antibody aa162‑211 Polyclonal IHC,Peptide‑ELISA,WB LS‑B6327

Note: This antibody replaces LS-C118402
Antibody:
Rabbit Polyclonal to Human CLDN1 / Claudin 1
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified
Price
Catalog Number
$254 
LS-B6327-100
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human CLDN1 / Claudin 1
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse, Rat
Format:
Unconjugated, Unmodified

Specifications

Description
CLDN1 (SEMP1) is a membrane protein of the claudin family. It is a component of tight junction complexes that regulate the permeability of epithelia. It is required to prevent the paracellular diffusion of small molecules through these junctions in the epidermis and for the normal barrier function of the skin. It is necessary for normal water homeostasis and to prevent excessive water loss through the skin, likely via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte junctions. Additionally, CLDN1 acts as a coreceptor for HCV entry into hepatic cells. In cancer, CLDN1 is a useful target in immunohistochemistry for identifying hemangiopericytoma and meningiomas, perineuriomas, ovarian adenocarcinomas in effusions, and as a general marker for epithelial differentiation. In normal tissue, CLDN1 shows particulate membranous staining in squamous epithelium and positivity in gastrointestinal, immune, endocrine, exocrine, muscle, lung, renal, kidney, breast, skin and reproductive tissues. J Invest Dermatol. 2013 May;133(5):1161-9, PMID: 23407391; Am J Surg Pathol 2002;26:1620, PMID:12459629; Mod Pathol 2005;18:1403, PMID:15920547; Am J Clin Pathol 2007;127:928, PMID:17509990; https://www.ncbi.nlm.nih.gov/pubmed/18520438, Am J Surg Pathol 2008;32:1088, PMID:18520438; Am J Clin Pathol 2006;125:203, PMID:16393681;
Target
Human CLDN1 / Claudin 1
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:200)
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:5000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide from human Claudin 1. (AA Range: 162-211)
Epitope
aa162-211
Specificity
Claudin 1 Antibody detects endogenous levels of total Claudin 1 protein.
Usage
Western Blot: Predicted MW 22 kDa
Presentation
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CLDN1 / Claudin 1
O95832 NM_021101 NP_066924.1

Validation

Anti-CLDN1 / Claudin 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
PathPlus™ Validated
Anti-CLDN1 / Claudin 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-CLDN1 / Claudin 1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

Publications (3)

Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen NJ, Orlando RC, Chen X. Gut. 2014 May;63:711-9.

Gastroesophageal reflux activates the NF- kappa B pathway and impairs esophageal barrier function in mice. Fang Y, Chen H, Hu Y, Djukic Z, Tevebaugh W, Shaheen NJ, Orlando RC, Hu J, Chen X. American journal of physiology. Gastrointestinal and liver physiology. 2013 Jul;305:G58-65.

Deeply located low-grade fibromyxoid sarcoma with FUS-CREB3L2 gene fusion in a 5-year-old boy with review of literature. Kurisaki-Arakawa A, Suehara Y, Arakawa A, Takagi T, Takahashi M, Mitani K, Kaneko K, Yao T, Saito T. Diagnostic pathology. 2014 9:163. (IHC; Human)

Reviews (0)

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Requested From: United States
Date Requested: 8/25/2019
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