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Catalog Number Size Price
LS-A771-100 100 µg (1 mg/ml) $425 
CALCR / Calcitonin Receptor Antibody - Anti-Calcitonin Receptor antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCR / Calcitonin Receptor Antibody - Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCR / Calcitonin Receptor Antibody - Anti-Calcitonin Receptor antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
CALCR / Calcitonin Receptor Antibody - Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal CALCR / Calcitonin Receptor Antibody (C‑Terminus, IHC) LS‑A771

PathPlus™ Polyclonal CALCR / Calcitonin Receptor Antibody (C‑Terminus, IHC) LS‑A771

Note: This antibody replaces LS-C77541
Antibody:
Rabbit Polyclonal to Human CALCR / Calcitonin Receptor
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A771-100
100 µg
1 mg/ml

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Rabbit Polyclonal to Human CALCR / Calcitonin Receptor
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Calcitonin receptor (CALCR) is a transmembrane G-protein coupled protein that is a high-affinity receptor for calcitonin. It is involved in maintaining calcium homeostasis and regulating osteoclast-mediated bone resorption. This receptor is expressed during development and is involved in morphogenesis. In addition to binding calcitonin, CALCR can complex with RAMP3 (receptor activity modifying protein) to bind amylin, which regulates pancreatic islet function and is involved in Type II diabetes. Polymorphisms in the gene are associated with susceptibility to osteoporosis, and different alternatively spliced protein isoforms may regulate biologic responses to calcitonin. Furthermore, loss of functional CALCR through somatic mutation in glioblastoma is associated with an aggressive phenotype and poor prognosis. In immunohistochemistry, CALCR has membranous positivity on neurons in the hypothalamus, in renal tubules, osteoclasts, the testis and kidney. References: J Clin Invest. 1992;90(5):1726-1735. doi: 10.1172/JCI116046; J Clin Invest. 1995;95(6):2680-2691. doi: 10.1172/JCI117970; Clin Cases Miner Bone Metab. 2007;4(2):117-122. PMID: 22461211; vMol Cell Proteomics. 2014;13(2):397-406. doi: 10.1074/mcp.M113.035600; The Journal of Cell Biology. 2004. 164 (4): 509–14, PMID: 14970190; Clin Cancer Res. 2018 Mar 15;24(6):1448-1458, PMID: 29263181;
Target
Human CALCR / Calcitonin Receptor
Synonyms
CALCR | Calcitonin receptor | CRT | CT-R | CTR | CT receptor
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Guinea pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (6.8 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 16 amino acid peptide from C-Terminus of human Calcitonin Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Guinea pig (94%); Rabbit (88%); Mouse, Horse (81%).
Blocking Peptide
LS-E29280 - Liquid - 50 µg 1 mg/ml - $145.00
Immunizing peptide used to generate LS-A771. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Specificity
Human Calcitonin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CALCR / Calcitonin Receptor
P30988 NM_001742 NP_001733.1

Validation

CALCR / Calcitonin Receptor Antibody - Anti-Calcitonin Receptor antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Calcitonin Receptor antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Calcitonin Receptor antibody IHC of human parathyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CALCR / Calcitonin Receptor Antibody - Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ CALCR / Calcitonin Receptor Antibody (C-Terminus) for IHC LS-A771 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Requested From: United States
Date Requested: 3/31/2020