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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-A772-100 100 µg (1 mg/ml) $425 
CALCR / Calcitonin Receptor Antibody - Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

PathPlus™ CALCR / Calcitonin Receptor Antibody C‑Terminus Polyclonal ELISA,IHC LS‑A772

PathPlus™ CALCR / Calcitonin Receptor Antibody C‑Terminus Polyclonal ELISA,IHC LS‑A772

Antibody:
Rabbit Polyclonal to Human CALCR / Calcitonin Receptor
Application:
IHC, IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$425 
LS-A772-100
100 µg
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human CALCR / Calcitonin Receptor
Application:
IHC, IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Calcitonin receptor (CALCR) is a transmembrane G-protein coupled protein that is a high-affinity receptor for calcitonin. It is involved in maintaining calcium homeostasis and regulating osteoclast-mediated bone resorption. Polymorphisms in the gene are associated with susceptibility to osteoporosis, and different alternatively spliced protein isoforms may regulate biologic responses to calcitonin. CALCR is expressed in osteoclasts and a variety of tissues including testis, kidney, and brain. J Clin Invest. 1992;90(5):1726-1735. doi: 10.1172/JCI116046; J Clin Invest. 1995;95(6):2680-2691. doi: 10.1172/JCI117970; Clin Cases Miner Bone Metab. 2007;4(2):117-122. PMID: 22461211; vMol Cell Proteomics. 2014;13(2):397-406. doi: 10.1074/mcp.M113.035600.
Target
Human CALCR / Calcitonin Receptor
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (20 µg/ml)
  • ELISA
  • Applications tested for the base form of this product only
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 19 amino acid peptide from C-terminal cytoplasmic domain of human Calcitonin Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey (95%); Marmoset, Dog, Panda, Guinea pig (84%).
Blocking Peptide
LS-E29281 - Liquid - 50 µg - $145.00
Immunizing peptide used to generate LS-A772. Useful for pre-absorption and neutralization of the antibody's antigen binding site.
Epitope
C-Terminus
Specificity
Human Calcitonin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Usage
Immunohistochemistry: The unconjugated form was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for the unconjugated form was determined to be 20 ug/ml.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CALCR / Calcitonin Receptor
P30988 NM_001742 NP_001733.1

Validation

CALCR / Calcitonin Receptor Antibody - Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-CALCR / Calcitonin Receptor antibody IHC of human Thyroid, Medullary Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

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Requested From: United States
Date Requested: 11/12/2019