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PathPlusTM TPRA1 / GPR175 Antibodies
Gpr175 (also known as TPRA1 or TPRA40: transmembrane protein, adipocyte associated 1 or of 40 kDa) is a GPCR that localizes to primary cilia upon Hh stimulation and positively regulates Hh signaling. Gpr175 or Gai1 depletion leads to increases in cellular cAMP levels and in Gli3 processing into its repressor form. Gpr175 coupled to Gai1 normally functions to inhibit the production of cAMP by adenylyl cyclase upon Hh stimulation, thus maximizing signaling by turning off PKA activity and hence Gli3 repressor formation.
References: October 8, 2015 doi: 10.1074/jbc.M115.665810jbc.M115.665810.
2 PathPlusTM Antibodies
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Antibodies
(2)
Type
Primary
(2)
Target
TPRA1 / GPR175
(2)
Reactivity
Human
(2)
Monkey
(2)
Rabbit
(1)
Application
IHC
(2)
IHC-P
(2)
ICC
(1)
Host
rabbit
(2)
Product Group
GPCR Database Antibodies
(2)
PathPlus Neuro
(2)
Clonality
polyclonal pc
(2)
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Unconjugated
(2)
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Cytoplasmic Domain
(1)
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(1)
Publications
No
(2)
Neuroscience
Fast Shipping
TPRA1 / GPR175 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
Neuroscience
Fast Shipping
TPRA1 / GPR175 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human, Monkey
ICC, IHC, IHC-P
Unconjugated
50 µg/$460
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