SGK2 is a serine/threonine-protein kinase that modulates the expression of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. It upregulates Na+ channel SCNN1A (ENAC), K+ channels KCNA3 (Kv1.3), KCNE1 and KCNQ1, amino acid transporter SLC6A19, glutamate transporter SLC1A6 (EAAT4), glutamate receptors GRIA1 (GLUR1) and GRIK2 (GLUR6), Na+/H+ exchanger SLC9A3 (NHE3), and the Na+/K+ ATPase. It also regulates the human organic anion transporter 4 (OAT4) via NEDD4. In immunohistochemistry, it has high expression in kidney proximal tubule cells, and is also found in the gastrointestinal tract, liver, pancreas, skeletal muscle, brain, adrenal and thyroid glands, skin, appendix and spleen, and in reproductive tissues. References: Biochem Pharmacol. 2016 Feb 15;102:120-129, PMID: 26740304