OGG1 is the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. The protein has been associated with obesity, muscle and metabolic disorders. References: Sci Rep. 2018 Oct 5;8(1):14886. doi: 10.1038/s41598-018-33151-1; PLoS One. 2012;7(12):e51697, PMID: 23284747