Complement component 5a receptor 2 (C5AR2) is involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. Instead C5AR2 modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. C5AR2 may be involved in coronary artery disease and in the pathogenesis of sepsis. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804