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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
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866-206-6909 (Toll Free North America)
206-577-4565 (International)
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PathPlusTM B2M / Beta 2 Microglobulin Antibodies
B2M / Beta 2 Microglobulin is a serum protein associated with major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. It is required for proper cell surface expression of the complex. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. In cancer, mutation, loss or deregulation of B2M is believed to be involved in aiding tumors in escaping the immune response and therapies. It is used as a marker in the diagnosis of multiple myeloma and lymphoma, where it is regularly overexpressed. It has elevated levels in a number of other cancers, including colorectal, breast, gastric, lung, prostate and testicular cancer as well as malignant epithelial ovarian tumors. B2M has membranous and cytoplasmic positivity in most normal tissues, with elevated levels in immune cells and macrophages. J Transl Med. 2016; 14: 75, PMID: 26983758; Cancer Discov. 2017 Dec; 7(12): 1420–1435, PMID: 29025772

5 PathPlusTM Antibodies
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Viewing 1-5 of 5 items
Mouse Monoclonal [clone 2M2] (IgG1) to Human B2M / Beta 2 Microglobulin
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $425.00
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Mouse Monoclonal [clone B2M-01] (IgG2a) to Human B2M / Beta 2 Microglobulin
Human
ELISA, Flo, ICC, IHC, IHC-P, IP, RIA, WB
Unconjugated
0.1mg   $425.00
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Mouse Monoclonal [clone B2M-02] (IgG1) to Human B2M / Beta 2 Microglobulin
Porcine, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
0.1mg   $425.00
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Goat Polyclonal to Human B2M / Beta 2 Microglobulin
Human
ELISA, Flo, ID, IHC, IHC-P, IP, WB
Unconjugated
0.1mg   8.81mg/ml   $425.00
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Rabbit Polyclonal (IgG) to Human B2M / Beta 2 Microglobulin
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $250.00
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