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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
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866-206-6909 (Toll Free North America)
206-577-4565 (International)
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PathPlusTM AGR2 Antibodies
AGR2 (Anterior gradient protein 2, XAG-2) is a protein disulfide isomerase that is required for MUC2 post-transcriptional synthesis and secretion and may play a role in the production of mucus by intestinal cells. It is also thought to be involved more broadly in cell migration, differentiation and growth, as well as in protein folding. As a biomarker, it is useful for identifying Barrett’s esophagus, where it has up to a 70-fold increase in expression over normal epithelia. AGR2 is also overexpressed in prostate, esophageal, pancreatic and ER-positive breast cancers as well as in cancer cell lines, where it is thought to contribute to invasive potential. In immunohistochemistry of normal tissue, AGR2 is expressed in mucus-secreting tissues including the lungs, colon, stomach, small intestine and prostate, as well as in genitalia. Cancer Res. 2008 Jan. 68 (2): 492–7, PMID: 18199544; Prostate. 2011 May;71(6):575-87, PMID: 20945500; Biochem. Biophys. Res. Commun. 1998. 251 (1): 111–6. PMID: 9790916; Gastroenterology. 2006 Sep. 131 (3): 925–33, PMID: 16952561; Cancer Res. 2008 Oct. 68 (19): 7811–8, PMID: 18829536; J. Biol. Chem. 2012. 287 (7): 4773–82, PMID: 22184114.

4 PathPlusTM Antibodies
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AGR2 (4)
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Rabbit Polyclonal (IgG) to Human AGR2
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $425.00
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Mouse Monoclonal (IgG1) to Human AGR2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
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Rabbit Polyclonal (IgG) to Human AGR2
Xenopus, Zebrafish, Horse, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $331.00
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Mouse Monoclonal (IgG1) to Human AGR2
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $400.00
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