ADGRD1 is an orphan adhesion G protein-coupled receptor that is transcriptionally upregulated by hypoxia in a Hif1a dependent manner. It is a critical regulator of the response to hypoxia and tumor growth in glioblastoma, and its expression levels are inversely correlated with patient survival. The receptor is widely expressed in human tissues.
References: Oncogenesis. 2016 Oct; 5(10): e263.