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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
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866-819-4732 (Toll Free North America
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PathPlusTM ACVRL1 Antibodies
ACVRL1 (Activin A receptor, type II-like 1, activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 protein deficiency and mutations in the gene cause hemorrhagic telangiectasia type 2 (HHT2), also known as Rendu-Osler-Weber syndrome 2 (ORW2), and also lead to pulmonary arteriovenous malformations. ACVRL1 interaction with low-density lipoprotein (LDL) also implicates it in the early phases of atherosclerosis. In immunohistochemistry of normal tissue, ACVRL1 has cytoplasmic positivity in the lung, placenta, brain, endocrine tissues, gastrointestinal tissue, gallbladder, pancreas, kidney, testis, smooth muscle, skin, and immune tissues. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Online Mendelian Inheritance in Man, OMIM®. Johns Hopkins University, Baltimore, MD. MIM Number: 600376: 08/22/2019: URL: https://omim.org/; Nature Communications. 7: 13516, PMID: 27869117;

1 PathPlusTM Antibody
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ACVRL1 Antibody - Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
Rabbit Polyclonal (IgG) to Human ACVRL1
Mouse, Rat, Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00

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