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| Catalog Number | Size | Price |
|---|---|---|
| LS-A1449-50 | 50 µg (1 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human TSH Receptor / TSHR Antibody (C‑Terminus, IHC) LS‑A1449
PathPlus™ Polyclonal Rabbit anti‑Human TSH Receptor / TSHR Antibody (C‑Terminus, IHC) LS‑A1449
Antibody:
TSH Receptor / TSHR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
TSH Receptor / TSHR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
TSHR (thyroid stimulating hormone receptor) is a thyrotropin and glycoprotein hormone receptor centrally involved in controlling thyroid cell metabolism. TSHR interacts with both TSH and autoantibodies against TSHR (thyroid-stimulating immunoglobulins, TSI). Mutations in the receptor cause hyperthyroidism including gestational hyperthyroidism (hypersensitivity to chorionic gonadotropin) and Grave's disease (autoimmune hyperthyroidism), for which TSHR is a therapeutic target.
References: Expert Opin Ther Targets. 2017 Apr;21(4):427-432, PMID: 28127991
Target
Human TSH Receptor / TSHR
Synonyms
TSHR | CHNG1 | HTSHR-I | LGR3 | Thyrotrophin receptor | TSH-R | TSH receptor | Thyrotropin receptor
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat, Dog, Guinea pig, Horse, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 19 amino acid peptide from C-Terminus of human TSH Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bat, Dog, Elephant, Horse, Pig, Guinea pig (94%); Mouse, Rat, Sheep, Cat, Bovine, Hamster, Panda, Rabbit, Opossum (89%).
Epitope
C-Terminus
Specificity
Human TSH Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except LHCGR (42%).
Applications
- IHC
- IHC - Paraffin (4 - 13 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About TSH Receptor / TSHR
Validation
Thyroid Papillary Carcinoma
Thyroid Papillary Carcinoma
Thyroid, Follicular Carcinoma
Thyroid, Follicular Carcinoma
Thyroid Papillary Carcinoma
Thyroid Papillary Carcinoma
Anti-TSH Receptor antibody IHC of human thyroid, follicular epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TSH Receptor antibody IHC of human thyroid, follicular epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TSH Receptor / TSHR antibody IHC of human Thyroid, Follicular Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TSH Receptor / TSHR antibody IHC of human Thyroid, Follicular Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ TSH Receptor / TSHR Antibody (C-Terminus) for IHC LS-A1449 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
