Human THBD / CD141 / Thrombomodulin
THBD | BDCA3 | CD141 antigen | CD141 | AHUS6 | Fetomodulin | THPH12 | TM | THRM | Thrombomodulin
(tested or 100% immunogen sequence identity)
Also available Azide-free, Carrier-free
Recombinant fragment (around aa 69-194) of human Thrombomodulin (CD141) protein. Antigen Molecular Weight: ~100 kDa
It recognizes a protein of 75 kDa , identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.