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Catalog Number Size Price
LS-B16258-100 100 µg (200 µg/ml) $485 
THBD / CD141 / Thrombomodulin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
THBD / CD141 / Thrombomodulin Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
THBD / CD141 / Thrombomodulin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
THBD / CD141 / Thrombomodulin Antibody - SDS-PAGE Analysis  Purified Thrombomodulin Mouse Recombinant MAb (rTHBD/1591). Confirmation of Purity and Integrity of Antibody.
THBD / CD141 / Thrombomodulin Antibody - Analysis of Protein Array containing >19,000 full-length human proteins usingThrombomodulin Recombinant Mouse Monoclonal Antibody (rTHBD/1591)  Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
THBD / CD141 / Thrombomodulin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
THBD / CD141 / Thrombomodulin Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
THBD / CD141 / Thrombomodulin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
THBD / CD141 / Thrombomodulin Antibody - SDS-PAGE Analysis  Purified Thrombomodulin Mouse Recombinant MAb (rTHBD/1591). Confirmation of Purity and Integrity of Antibody.
THBD / CD141 / Thrombomodulin Antibody - Analysis of Protein Array containing >19,000 full-length human proteins usingThrombomodulin Recombinant Mouse Monoclonal Antibody (rTHBD/1591)  Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD’s) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD’s) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target.  A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.
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PathPlus™ Recombinant Monoclonal Mouse anti‑Human THBD / CD141 / Thrombomodulin Antibody (clone rTHBD/1591, aa 69‑194, IHC) LS‑B16258

PathPlus™ Recombinant Monoclonal Mouse anti‑Human THBD / CD141 / Thrombomodulin Antibody (clone rTHBD/1591, aa 69‑194, IHC) LS‑B16258

Note: This antibody replaces LS-C751386
Antibody:
THBD / CD141 / Thrombomodulin Mouse anti-Human Recombinant Monoclonal (aa 69-194) (rTHBD/1591) Antibody
Application:
IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$485
LS-B16258-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
THBD / CD141 / Thrombomodulin Mouse anti-Human Recombinant Monoclonal (aa 69-194) (rTHBD/1591) Antibody
Application:
IHC-P, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
THBD (Thrombomodulin; CD141) is an endothelial-specific type I membrane receptor that binds thrombin. Binding of THBD to thrombin leads to decreased fibrinogen-to-fibrin conversion and activation of the coagulation cascade. The THBD/thrombin complex catalyzes protein C activation, which increases inhibition of coagulation by inactivating cofactors Va and VIIIa. Mutations in this gene are implicated in inherited thrombophilia and recurrent pregnancy loss. References: Reprod Biol Endocrinol 2017 15:92
Target
Human THBD / CD141 / Thrombomodulin
Synonyms
THBD | BDCA3 | CD141 antigen | CD141 | AHUS6 | Fetomodulin | THPH12 | TM | THRM | Thrombomodulin
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Recombinant Monoclonal
Clone
rTHBD/1591
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified. Also available Azide-free, Carrier-free.
Immunogen
Recombinant fragment (around aa 69-194) of human Thrombomodulin (CD141) protein. Antigen Molecular Weight: ~100 kDa
Epitope
aa 69-194
Specificity
It recognizes a protein of 75 kDa , identified as Thrombomodulin. Thrombomodulin is a transmembrane glycoprotein with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytio-trophoblasts of placenta also express thrombomodulin. This protein is present in almost all of benign vascular tumors and majority of malignant vascular tumors (Kaposi s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. Recently, thrombomodulin antibody has been used for mesothelial cells and malignant mesotheliomas.
Applications
  • IHC - Paraffin (1:50)
  • ELISA (2 - 4 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 1-2 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris buffer with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About THBD / CD141 / Thrombomodulin
P07204 NM_000361 NP_000352.1

Validation

THBD / CD141 / Thrombomodulin Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

THBD / CD141 / Thrombomodulin Antibody - Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE)

THBD / CD141 / Thrombomodulin Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ THBD / CD141 / Thrombomodulin Antibody (aa 69-194, clone rTHBD/1591) for IHC, ELISA LS-B16258 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/16/2021