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Catalog Number Size Price
LS-B16302-100 100 µg (200 µg/ml) $485 
TG / Thyroglobulin Antibody - Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
TG / Thyroglobulin Antibody - SDS-PAGE Analysis of Purified Thyroglobulin Rabbit Recombinant Monoclonal Antibody (TGB/1968R). Confirmation of Purity and Integrity of Antibody.
TG / Thyroglobulin Antibody - Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
TG / Thyroglobulin Antibody - SDS-PAGE Analysis of Purified Thyroglobulin Rabbit Recombinant Monoclonal Antibody (TGB/1968R). Confirmation of Purity and Integrity of Antibody.
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human TG / Thyroglobulin Antibody (clone TGB/1968R, IHC) LS‑B16302

PathPlus™ Recombinant Monoclonal Rabbit anti‑Human TG / Thyroglobulin Antibody (clone TGB/1968R, IHC) LS‑B16302

Note: This antibody replaces LS-C751387
Antibody:
TG / Thyroglobulin Rabbit anti-Human Recombinant Monoclonal (TGB/1968R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$485
LS-B16302-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
TG / Thyroglobulin Rabbit anti-Human Recombinant Monoclonal (TGB/1968R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Thyroglobulin (TG) is a protein synthesized by follicular cells of the thyroid, and is the precursor for thyroid hormones T3 and T4. Serum thyroglobulin measurements can be used as a marker for thyroid tumors, particularly in the postoperative management period, as well as a sensitive biomarker of iodine status in iodine deficiency states. Mutations in this gene are implicated in thyroid dyshormonogenesis with goiter, and congenital hypothyroidism. Polymorphisms are associated with autoimmune thyroid diseases such as Grave’s and Hashimoto’s thyroiditis. References: Nature Clin Practice 2008 4(4):223; Thyroid 2014 24(8):1195; Clin Endocrin 2004 61(2):263; Mol Med Reports 2015 12(3):4469
Target
Human TG / Thyroglobulin
Synonyms
TG | AITD3 | TDH3 | Thyroglobulin | TGN
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Recombinant Monoclonal
Clone
TGB/1968R
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified. Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human Thyroglobulin protein. Antigen Molecular Weight: 660 kDa (Dimeric Form)
Specificity
Thyroglobulin is a 660 kDa dimeric pre-protein with multiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine.  Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation.  The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
Applications
  • IHC - Paraffin (1:200)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 0.5-1.0 ug/ml for 30 min at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About TG / Thyroglobulin
P01266 NM_003235 NP_003226.4

Validation

TG / Thyroglobulin Antibody - Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Thyroid: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ TG / Thyroglobulin Antibody (clone TGB/1968R) for IHC LS-B16302 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021