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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Catalog Number Size Price
LS-B5232-50 50 µl (1 mg/ml) $425 
SYNCAM / CADM1 Antibody - Anti-CADM1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
SYNCAM / CADM1 Antibody - Western blot analysis of lysates from HeLa cells, using CADM1 Antibody. The lane on the right is blocked with the synthesized peptide.
SYNCAM / CADM1 Antibody - Anti-CADM1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
SYNCAM / CADM1 Antibody - Western blot analysis of lysates from HeLa cells, using CADM1 Antibody. The lane on the right is blocked with the synthesized peptide.
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PathPlus Neuro PathPlus™ SYNCAM / CADM1 Antibody aa393‑442 Polyclonal IHC,Peptide‑ELISA,WB LS‑B5232

PathPlus Neuro PathPlus™ SYNCAM / CADM1 Antibody aa393‑442 Polyclonal IHC,Peptide‑ELISA,WB LS‑B5232

Note: This antibody replaces LS-C119422
Antibody:
Rabbit Polyclonal to Human SYNCAM / CADM1
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Price
Catalog Number
$425 
LS-B5232-50
50 µl
1 mg/ml
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human SYNCAM / CADM1
Application:
IHC, IHC-P, WB, Peptide-ELISA
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified

Specifications

Description
CADM1 (Cell adhesion molecule 1, BL2, IGSF4) is a membrane glycoprotein of the immunoglobulin superfamily. It is involved in cell-cell interaction, epithelial and synaptic adhesion, neural development and tumor suppression. In the brain, it is expressed on Purkinje cell dendrites in the cerebellum and on neural dendrites in the hippocampus. Inherited mutations in CADM1 are correlated with autism. Furthermore, knockout studies in mice indicate that loss of CADM1 results in arrested spermatogenesis and infertility. CADM1 has also been found to function in the suppression of tumor motility and invasive characteristics. In breast cancer, loss of CADM1 is an indicator of poor prognosis and metastasis to the brain. Similarly, higher expression of CADM1 in melanoma and squamous cell carcinoma of the lung is associated with better survival. In immunohistochemistry of normal tissue, CADM1 has high membranous positivity in the central nervous system, and is also expressed on most glandular cells, basolateral renal tubule membranes, and islets of Langerhans in the pancreas. Oncotarget. 2014 May 30;5(10):3076-87, PMID: 24833255; J. Neurochem.2012. 2012 (123): 886–894, DOI: 10.1111/jnc.12022; Front Cell Dev Biol. 2018; 6: 86, PMID: 30131958; Cell Death & Diseasevolume 10, Article number: 281 (2019); Cell Death Dis. 2019 Mar 25;10(4):281, PMID: 30911007; Scientific Reports. Volume 6, Article number: 24006 (2016);
Target
Human SYNCAM / CADM1
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (1:200)
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:20000)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic peptide from human CADM1. (AA Range: 393-442)
Epitope
aa393-442
Specificity
CADM1 Antibody detects endogenous levels of total CADM1 protein.
Usage
Western Blot: Predicted MW 48 kDa
Presentation
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About SYNCAM / CADM1
Q9BY67 NM_014333 NP_055148.3

Validation

SYNCAM / CADM1 Antibody - Anti-CADM1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Anti-CADM1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
PathPlus™ Validated
Anti-CADM1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.

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Featured Products

SYNCAM / CADM1 Antibody - Anti-CADM1 antibody IHC of human colon, lamina propria macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
Species: Rat, Human
Applications: IHC, IHC - Paraffin, Western blot
SYNCAM / CADM1 Antibody - Anti-CADM1 antibody IHC of human colon, lamina propria macrophages. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
Species: Rat, Human
Applications: IHC, IHC - Paraffin, Western blot
Product
Species: Human, Mouse
Applications: IHC, Western blot, ELISA
SYNCAM / CADM1 Antibody - CADM1 antibody (1 ug/ml) staining of Mouse fetal Heart lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit
Applications: Western blot, Peptide Enzyme-Linked Immunosorbent Assay
SYNCAM / CADM1 Antibody - WB of SYNCAM / CADM1 antibody. All lanes: Anti-CADM1 at 0.5ug/ml. Lane 1: A549 Whole Cell Lysate at 40ug. Lane 2: JURKAT Whole Cell Lysate at 40ug. Lane 3: RAJI Whole Cell Lysate at 40ug. Lane 4: HELA Whole Cell Lysate at 40ug. Predicted bind size: 60KD. Observed bind size: 60KD.
Species: Human, Mouse, Rat
Applications: Western blot
SYNCAM / CADM1 Antibody - CADM1 antibody immunohistochemistry of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot

Requested From: United States
Date Requested: 10/20/2019