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Catalog Number Size Price
LS-A4751-50 50 µg (1 mg/ml) $460 
RXFP2 / LGR8 Antibody - Skin, Malignant Melanoma
RXFP2 / LGR8 Antibody - Breast, carcinoma
RXFP2 / LGR8 Antibody - Lung, non small-cell carcinoma
RXFP2 / LGR8 Antibody - Brain, Glioblastoma
RXFP2 / LGR8 Antibody - Anti-RXFP2 / LGR8 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
RXFP2 / LGR8 Antibody - Lung, Non Small-Cell Carcinoma
RXFP2 / LGR8 Antibody - Anti-RXFP2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
RXFP2 / LGR8 Antibody - Skin, Malignant Melanoma
RXFP2 / LGR8 Antibody - Breast, carcinoma
RXFP2 / LGR8 Antibody - Lung, non small-cell carcinoma
RXFP2 / LGR8 Antibody - Brain, Glioblastoma
RXFP2 / LGR8 Antibody - Anti-RXFP2 / LGR8 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
RXFP2 / LGR8 Antibody - Lung, Non Small-Cell Carcinoma
RXFP2 / LGR8 Antibody - Anti-RXFP2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human RXFP2 / LGR8 Antibody (Extracellular Domain, IHC) LS‑A4751

PathPlus™ Polyclonal Rabbit anti‑Human RXFP2 / LGR8 Antibody (Extracellular Domain, IHC) LS‑A4751

Note: This antibody replaces LS-C67004
Antibody:
RXFP2 / LGR8 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A4751-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
RXFP2 / LGR8 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Mouse
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
RXFP2 (LGR8) is a receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. It is also a receptor for Leydig insulin-like peptide (INSL3), and disruption in INSL3/RXFP2 signaling due to mutations in either gene results in intraabdominal cryptorchidism in mice. RXFP2 has been shown to be important for testis descent. In immunohistochemistry, RXFP2 has membranous positivity in the testes, brain, uterus, adipose tissue, thyroid, adrenal gland, reproductive tissues, smooth muscle, bone marrow, peripheral blood leukocytes, and skeletal muscle. It is also rpesent on neuroendocrine cells of the small intsestine and on macrophages. In the brain, RXFP2 is present on subsets of neurons in the medulla, with less intensive staining in the hippocampus and amygdala. References: Ann N Y Acad Sci. 2009 Apr;1160:197-204, PMID: 19416188
Target
Human RXFP2 / LGR8
Synonyms
RXFP2 | G-protein coupled receptor 106 | GPR106 | INSL3R | LGR8 | GREAT | Relaxin receptor 2 | LGR8.1 | RXFPR2
Host
Rabbit
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat, Horse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 17 amino acid peptide from 2nd extracellular domain of human RXFP2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Marmoset, Elephant, Panda, Bat, Horse (94%); Monkey, Dog, Pig (88%); Bovine, Rabbit, Platypus, Xenopus (82%).
Epitope
Extracellular Domain
Specificity
Human RXFP2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RXFP1 (53%).
Applications
  • IHC
  • IHC - Paraffin (18 - 72 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About RXFP2 / LGR8
Q8WXD0 NM_130806 NP_570718.1

Validation

RXFP2 / LGR8 Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

RXFP2 / LGR8 Antibody - Breast, carcinoma
Breast, carcinoma
Breast, carcinoma

RXFP2 / LGR8 Antibody - Lung, non small-cell carcinoma
Lung, non small-cell carcinoma
Lung, non small-cell carcinoma

RXFP2 / LGR8 Antibody - Brain, Glioblastoma
Brain, Glioblastoma
Brain, Glioblastoma

RXFP2 / LGR8 Antibody - Anti-RXFP2 / LGR8 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-RXFP2 / LGR8 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-RXFP2 / LGR8 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

RXFP2 / LGR8 Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

RXFP2 / LGR8 Antibody - Anti-RXFP2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-RXFP2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-RXFP2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ RXFP2 / LGR8 Antibody (Extracellular Domain) for IHC LS-A4751 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Developmental expression and gene regulation of insulin-like 3 receptor RXFP2 in mouse male reproductive organs. Feng S, Bogatcheva NV, Truong A, Korchin B, Bishop CE, Klonisch T, Agoulnik IU, Agoulnik AI. Biology of reproduction. 2007 77:671-80. (IHC-P; Mouse)

Customer Reviews (0)


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Requested From: United States
Date Requested: 9/28/2021