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NEFH / NF-H

neurofilament, heavy polypeptide

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene.

Gene Name: neurofilament, heavy polypeptide
Synonyms: NEFH, 200 kDa neurofilament protein, KIAA0845, NFH, NF-H
Target Sequences: NM_021076 NP_066554.2 P12036

Publications (3)

1
Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 26:981-90. [PubMed:16421318]
2
Caveolin-1 deficiency increases cerebral ischemic injury. Jasmin JF, Malhotra S, Singh Dhallu M, Mercier I, Rosenbaum DM, Lisanti MP. Circulation research. 2007 100:721-9. [PubMed:17293479]
3
Neurofilament protein levels: quantitative analysis in essential tremor cerebellar cortex. Louis ED, Ma K, Babij R, Corts E, Liem RK, Vonsattel JP, Faust PL. Neuroscience letters. 2012 518:49-54. (IHC, WB; Human) [PubMed:22561033] [PMC:PMC3364538]

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NEFH / NF-H Antibody - Anti-NEFH antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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NEFH / NF-H Mouse anti-Human Monoclonal (NF-05) Antibody
Porcine, Rat, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$460
NEFH / NF-H Antibody - Western blot of rat cortex lysate showing specific immunolabeling of the ~200k NF-H protein.
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NEFH / NF-H Mouse anti-Bovine Monoclonal Antibody
Chicken, Bovine, Mammal
IF, WB
Unconjugated
100 µl/$436
NEFH / NF-H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
NEFH / NF-H ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
NEFH / NF-H Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
NEFH / NF-H ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NEFH / NF-H ELISA Kit
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Sandwich
96-Well Strip Plate
Human
3.12 - 200 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NEFH / NF-H Antibody - Anti-NEFH antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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NEFH / NF-H Mouse anti-Human Monoclonal (RNF404) Antibody
Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
0.05 mg/$460
NEFH / NF-H Antibody - Immunostaining of cultured neurons and glia with anti-chicken neurofilament H antibody (red) and anti-neurofilament L antibody (green).
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NEFH / NF-H Chicken anti-Bovine Polyclonal Antibody
Chicken, Bovine, Mouse, Rat, Human
ICC, IF, WB
Unconjugated
100 µl/$436
NEFH / NF-H Antibody - Anti-NEFH / NF-H antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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Neuroscience
NEFH / NF-H Chicken anti-Bovine Polyclonal Antibody
Bovine, Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$485
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NEFH / NF-H Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$351
NEFH / NF-H Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Fast Shipping
NEFH / NF-H Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
NEFH / NF-H Antibody - Anti-NEFH antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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NEFH / NF-H Mouse anti-Human Monoclonal (RNF405) Antibody
Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
50 µg/$460
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NEFH / NF-H Mouse anti-Rat Monoclonal Antibody
Rat, Human
IHC, WB
Unconjugated
50 µg/$884
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NEFH / NF-H Mouse anti-Human Monoclonal (NF-01) Antibody
Chicken, Bovine, Rat, Pig, Mouse, Human
ELISA, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$832
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NEFH / NF-H Mouse anti-Human Monoclonal (Concentrated) (NF-01) Antibody
Human
ELISA, ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated, Concentrated
0.1 mg/$508
NEFH / NF-H Antibody - Neurofilament antibody NF421 immunohistochemistry cerebellum.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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NEFH / NF-H Mouse anti-Human Monoclonal (NF421) Antibody
Chicken, Rat, Pig, Mouse, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
NEFH / NF-H Antibody - Neurofilament antibody NF421 immunohistochemistry cerebellum.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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NEFH / NF-H Mouse anti-Human Monoclonal (Ready-to-Use) (NF421) Antibody
Chicken, Rat, Pig, Mouse, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
NEFH / NF-H Antibody - Neurofilament antibody NF421 immunohistochemistry cerebellum.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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NEFH / NF-H Mouse anti-Human Monoclonal (Azide-free, BSA-free) (NF421) Antibody
Chicken, Rat, Pig, Mouse, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
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NEFH / NF-H Mouse anti-Human Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human
IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$564
NEFH / NF-H Antibody - Human cerebellar cortex fixed in formalin, embedded in paraffin and stained with NEFH / NF-H antibody using the ABC (avidin biotin conjugate) method. The section was counterstained with hematoxylin-Eosin (blue). NEFH / NF-H antibody stains prominent basket cell axons surrounding the large Purkinje neurons. Granule cell layer at bottom of image, molecular layer at top.
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NEFH / NF-H Mouse anti-Pig Monoclonal (NAP4) Antibody
Chicken, Mammal
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$376
NEFH / NF-H Antibody - Neurofilament Heavy antibody RT97 immunohistochemistry cerebellum.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NEFH / NF-H Mouse anti-Rat Monoclonal (RT97) Antibody
Chicken, Rat, Pig, Mouse, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
NEFH / NF-H Antibody - Neurofilament Heavy antibody RT97 immunohistochemistry cerebellum.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NEFH / NF-H Mouse anti-Rat Monoclonal (Azide-free, BSA-free) (RT97) Antibody
Chicken, Rat, Pig, Mouse, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
NEFH / NF-H Antibody - Neurofilament Heavy antibody RT97 immunohistochemistry cerebellum.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NEFH / NF-H Mouse anti-Rat Monoclonal (Ready-to-Use) (RT97) Antibody
Chicken, Rat, Pig, Mouse, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
Select
NEFH / NF-H Mouse anti-Human Monoclonal Antibody
Xenopus, Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Human, Monkey
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$658
Viewing 1-25 of 109 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).