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Catalog Number Size Price
LS-B16291-100 100 µg (200 µg/ml) $485 
Mucin 2 / MUC2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mucin 2 / MUC2 Antibody - SDS-PAGE Analysis Purified MUC2 Rabbit Recombinant Monoclonal Antibody (MLP/2970R). Confirmation of Purity and Integrity of Antibody.
Mucin 2 / MUC2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Mucin 2 / MUC2 Antibody - SDS-PAGE Analysis Purified MUC2 Rabbit Recombinant Monoclonal Antibody (MLP/2970R). Confirmation of Purity and Integrity of Antibody.
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PathPlus™ Recombinant Monoclonal Rabbit anti‑Human Mucin 2 / MUC2 Antibody (clone MLP/2970R, IHC) LS‑B16291

PathPlus™ Recombinant Monoclonal Rabbit anti‑Human Mucin 2 / MUC2 Antibody (clone MLP/2970R, IHC) LS‑B16291

Note: This antibody replaces LS-C751283
Antibody:
Mucin 2 / MUC2 Rabbit anti-Human Recombinant Monoclonal (MLP/2970R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$485
LS-B16291-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
Mucin 2 / MUC2 Rabbit anti-Human Recombinant Monoclonal (MLP/2970R) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
MUC2 is a member of the mucin family of secreted glycoproteins that produces an insoluble mucous barrier in the gastrointestinal tract. MUC2 is implicated in the progression of ulcerative colitis, where it is downregulated. It has also been implicated in the formation or colorectal cancers. A MUC2 knockout model in mice demonstrated a propensity for colorectal cancer in its absence, as these mice frequently developed invasive colorectal adenocarcinomas. Staining is expected to be cytoplasmic within intestinal goblet cells and airway epithelium, and potentially in secretions, as well as within mucinous carcinomas of the colon, breast, pancreas, ovary, and stomach. References: Allen, 1998; Moehle, 2006; Betge, 2016; Velcich, 2002; Oncotarget 2017 8(42):71456; Am J Surg Path 2005 29(3):359
Target
Human Mucin 2 / MUC2
Synonyms
MUC2 | Intestinal mucin-2 | Mucin-like protein | MUC-2 | Mucin 2, intestinal/tracheal | Mucin 2 | Mucin-2 | MLP | SMUC
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Recombinant Monoclonal
Clone
MLP/2970R
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified. Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human MUC2 protein. Antigen Molecular Weight: 520 kDa
Specificity
Recognizes a single glycoprotein of 520 kDa , identified as mucin 2 (MUC2). This MAb shows no cross-reaction with human milk fat globule membranes, MUC1, or MUC3. Its epitope has been defined as  GTQTP (GlyThrGlnThrPro). Mucins are high molecular weight glycoproteins, which constitute the major component of the mucus layer that protects the gastric epithelium. MUC2 is specifically expressed in goblet cells of the small intestine & colon; in about 65% of colonic carcinomas and about 40% of gastric carcinomas. MUC2 is rarely expressed outside of the GI tract with the exceptions of mucinous carcinoma of breast and clear cell-type carcinomas of the ovary.
Applications
  • IHC - Paraffin (1:100)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 0.5-1 ug/ml for 30 minutes at RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris-HCl buffer, pH 10.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About Mucin 2 / MUC2
Q02817 NM_002457 NP_002448.3

Validation

Mucin 2 / MUC2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ Mucin 2 / MUC2 Antibody (clone MLP/2970R) for IHC LS-B16291 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021