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Catalog Number Size Price
LS-A1531-50 50 µg (1 mg/ml) $460 
MAS1 / MAS Antibody - Breast carcinoma
MAS1 / MAS Antibody - Lung, non small-cell carcinoma
MAS1 / MAS Antibody - Pancreas, Carcinoma
MAS1 / MAS Antibody - Anti-MAS1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
MAS1 / MAS Antibody - Anti-MAS1 / MAS antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
MAS1 / MAS Antibody - Breast, Carcinoma
MAS1 / MAS Antibody - Lung, Non Small-Cell Carcinoma
MAS1 / MAS Antibody - Breast carcinoma
MAS1 / MAS Antibody - Lung, non small-cell carcinoma
MAS1 / MAS Antibody - Pancreas, Carcinoma
MAS1 / MAS Antibody - Anti-MAS1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
MAS1 / MAS Antibody - Anti-MAS1 / MAS antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
MAS1 / MAS Antibody - Breast, Carcinoma
MAS1 / MAS Antibody - Lung, Non Small-Cell Carcinoma
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PathPlus™ Polyclonal Rabbit anti‑Human MAS1 / MAS Antibody (C‑Terminus, IHC) LS‑A1531

PathPlus™ Polyclonal Rabbit anti‑Human MAS1 / MAS Antibody (C‑Terminus, IHC) LS‑A1531

Antibody:
MAS1 / MAS Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A1531-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
MAS1 / MAS Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
MAS1 (MAS proto-oncogene) is a G protein-coupled receptor for angiotensin (1-7), an active RAS (renin-angiotensin system) heptapepide that functions as a vasodilator agent in cardiovascular organs. MAS1 is a functional antagonist of angiotensin-2 type 1 receptor (AGTR1), which it also upregulates. This occurs through G-protein GNA11 and GNAQ activation and through stimulation of the protein kinase C signaling cascade. MAS1 may have neuroprotective effects via Angiotensin (1-7) binding and loss of this receptor increases cerebral inflammation in mice. Furthermore, induced activation of MAS1 through angiotensin (1-7) treatment therapies seems to relieve bone pain in some cancer patients. In immunohistochemistry, MAS1 is has membranous positivity primarily in the cerebral cortex, hippocampus and amygdala in the brain, and it also has some expression in reproductive tissues, immune tissues, and blood. References: Br J Pharmacol. 2017 May; 174(9): 737–753, PMID: 28194766
Target
Human MAS1 / MAS
Synonyms
MAS1 | Mas proto-oncogene | Proto-oncogene Mas | MAS | MAS1 oncogene
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 17 amino acid peptide from C-Terminus of human MAS1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Monkey (94%); Elephant, Panda (88%); Mouse, Rat, Hamster (82%).
Epitope
C-Terminus
Specificity
Human MAS1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (15 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About MAS1 / MAS
P04201 NM_002377 NP_002368.1

Validation

MAS1 / MAS Antibody - Breast carcinoma
Breast carcinoma
Breast carcinoma

MAS1 / MAS Antibody - Lung, non small-cell carcinoma
Lung, non small-cell carcinoma
Lung, non small-cell carcinoma

MAS1 / MAS Antibody - Pancreas, Carcinoma
Pancreas, Carcinoma
Pancreas, Carcinoma

MAS1 / MAS Antibody - Anti-MAS1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MAS1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MAS1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

MAS1 / MAS Antibody - Anti-MAS1 / MAS antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MAS1 / MAS antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MAS1 / MAS antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

MAS1 / MAS Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

MAS1 / MAS Antibody - Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma
Lung, Non Small-Cell Carcinoma

LSBio Ratings

PathPlus™ MAS1 / MAS Antibody (C-Terminus) for IHC LS-A1531 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021