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Catalog Number Size Price
LS-A442-50 50 µg (1 mg/ml) $440 
LGR6 Antibody - Skin, melanoma
LGR6 Antibody - Anti-LGR6 antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LGR6 Antibody - Brain, Amygdala
LGR6 Antibody - Brain, Alzheimer's disease, neuritic plaque
LGR6 Antibody - Skin, melanoma
LGR6 Antibody - Anti-LGR6 antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
LGR6 Antibody - Brain, Amygdala
LGR6 Antibody - Brain, Alzheimer's disease, neuritic plaque
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PathPlus™ Polyclonal Rabbit anti‑Human LGR6 Antibody (N‑terminal extracellular domain, IHC) LS‑A442

PathPlus™ Polyclonal Rabbit anti‑Human LGR6 Antibody (N‑terminal extracellular domain, IHC) LS‑A442

Antibody:
LGR6 Rabbit anti-Human Polyclonal (N-terminal extracellular domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-A442-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
LGR6 Rabbit anti-Human Polyclonal (N-terminal extracellular domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
Leucine-rich repeat containing G protein-coupled receptor 6 (LGR6) is a receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), it associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, it does not activate heterotrimeric G-proteins to transduce the signal. LGR6 may act as a tumor suppressor. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human LGR6
Synonyms
LGR6 | VTS20631
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from human LGR6. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Marmoset (95%); Rabbit (80%).
Epitope
N-terminal extracellular domain
Specificity
Human LGR6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (4 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About LGR6
Q9HBX8 AB049405 CAD13082.1

Validation

LGR6 Antibody - Skin, melanoma
Skin, melanoma
Skin, melanoma

LGR6 Antibody - Anti-LGR6 antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LGR6 antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LGR6 antibody IHC of human brain, neuron. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LGR6 Antibody - Brain, Amygdala
Brain, Amygdala
Brain, Amygdala

LGR6 Antibody - Brain, Alzheimer's disease, neuritic plaque
Brain, Alzheimer's disease, neuritic plaque
Brain, Alzheimer's disease, neuritic plaque

LSBio Ratings

PathPlus™ LGR6 Antibody (N-terminal extracellular domain) for IHC LS-A442 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)

Publications (1)

Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions. Nan Chiang, Stephania Libreros, Paul C Norris, Xavier de la Rosa, Charles N Serhan. The Journal of clinical investigation. 2019 Dec;129:5294-5311.

Customer Reviews (0)


Request SDS/MSDS

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Technical.Support@LSBio.com

Requested From: United States
Date Requested: 10/8/2024