ITGAX (CD11c) is the integrin alpha X chain protein that functions as a fibrinogen receptor. ITGAX plays a role in monocyte adhesion and chemotaxis, and can induce cellular activation and trigger neutrophil respiratory burst. In cancer, it is positive in leukemia, including the hairy cell, acute nonlymphocytic and B-cell chronic lymphocytic subtypes, and follicular and lymphoplasmacytic lymphoma. In obesity, CD206 and TGAX / CD11c positive macrophages in adipose tissue are correlated with insulin resistance. In immunohistochemistry, ITGAX is found on dendritic cells, monocytes, granulocytes, macrophages, neutrophils, some B cells, as well as roughly half of activated CD4 and CD8 positive T cells. It is commonly used to identify histiocytes and NK cells, and also in the diagnosis of leukemia.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804; Diabetes 2010;59:1648, PMID: 20357360; McKusick, Hamosh. Online Mendelian Inheritance in Man, OMIM. Johns Hopkins University, Baltimore, MD. MIM Number: 151510, URL: https://omim.org/ OMIM: 151510; Am J Clin Pathol 2005;124:414, PMID: 16191510; Am J Clin Pathol 1998;110:582, PMID: 9802342;