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Catalog Number	Size	Price
LS-A650-50	50 µg (1 mg/ml)	$440

HTR6 / 5-HT6 Receptor Antibody - Brain, Basal Ganglia

HTR6 / 5-HT6 Receptor Antibody - Brain, substantia nigra

HTR6 / 5-HT6 Receptor Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

HTR6 / 5-HT6 Receptor Antibody - Anti-HTR6 / 5-HT6 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HTR6 / 5-HT6 Receptor Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)

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PathPlus™ Polyclonal Rabbit anti‑Human HTR6 / 5‑HT6 Receptor Antibody (C‑Terminus, IHC) LS‑A650

Name: PathPlus™ HTR6 / 5-HT6 Receptor Polyclonal Antibody Rabbit IHC | LSBio
Brand: Lifespan BioSciences
SKU: LS-A650-50
Price: 440.0000 USD
Availability: InStock
Rating: 5 (1 reviews)

Neuroscience

(5.0) Rating

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Antibody:

HTR6 / 5-HT6 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Application:

IHC, IHC-P

Reactivity:

Human

Format:

Unconjugated, Unmodified

$440

LS-A650-50

Ready To Ship

Toll Free North America

206-374-1102

For Research Use Only

Specifications Validation Publications Reviews Featured Products Request SDS/MSDS

Overview

Antibody:

HTR6 / 5-HT6 Receptor Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Application:

IHC, IHC-P

Reactivity:

Human

Format:

Unconjugated, Unmodified

Specifications

Description

5-HT6 receptor (HTR6) is a Serotonin Receptor that regulates cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. HTR6 predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion. Some antidepressants and antipsychotics are potent 5-HT6 Receptor antagonists, making this gene valuable for the pharmaceutical industry. 5-HT6 may be involved in the pathogenesis of mood disorders, schizophrenia, and Alzheimer's disease. A splice variant that has a 289bp deletion in the transmembrane region IV and the third intracellular loop has been isolated. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804

Target

Human HTR6 / 5-HT6 Receptor

Synonyms

See All HTR6 / 5-HT6 Receptor Antibodies

Host

Rabbit

Reactivity

Human (tested or 100% immunogen sequence identity)

Predicted

Monkey, Horse (at least 90% immunogen sequence identity)

Clonality

Polyclonal

Conjugations

Unconjugated

Purification

Immunoaffinity purified

Modifications

Unmodified

Immunogen

Synthetic 17 amino acid peptide from C-Terminus of human HTR6 / 5-HT6. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla (100%); Monkey, Horse (94%); Gibbon, Dog, Rabbit (88%); Elephant (82%).

Epitope

C-Terminus

Specificity

Human HTR6 / 5-HT6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Applications

IHC
IHC - Paraffin (2.5 - 5 µg/ml)

Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.

Presentation

PBS, 0.1% Sodium Azide

Storage

Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.

Restrictions

For research use only. Intended for use by laboratory professionals.

Guarantee

This antibody carries the LSBio 100% Guarantee.

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About HTR6 / 5-HT6 Receptor

Uniprot: P50406 NCBI: NM_000871 NP_000862.1

Validation

Brain, Basal Ganglia

Brain, substantia nigra

Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-HTR6 / 5-HT6 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.