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Catalog Number Size Price
LS-A1187-50 50 µg (1 mg/ml) $440 
HTR2B / 5-HT2B Receptor Antibody - Brain, Amygdala neurons
HTR2B / 5-HT2B Receptor Antibody - Brain, Substantia Nigra
HTR2B / 5-HT2B Receptor Antibody - Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HTR2B / 5-HT2B Receptor Antibody - Anti-5HT2B Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HTR2B / 5-HT2B Receptor Antibody - Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HTR2B / 5-HT2B Receptor Antibody - Brain, Amygdala neurons
HTR2B / 5-HT2B Receptor Antibody - Brain, Substantia Nigra
HTR2B / 5-HT2B Receptor Antibody - Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HTR2B / 5-HT2B Receptor Antibody - Anti-5HT2B Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
HTR2B / 5-HT2B Receptor Antibody - Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human HTR2B / 5‑HT2B Receptor Antibody (N‑Terminus, IHC) LS‑A1187

PathPlus™ Polyclonal Rabbit anti‑Human HTR2B / 5‑HT2B Receptor Antibody (N‑Terminus, IHC) LS‑A1187

Antibody:
HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$440
LS-A1187-50

Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
HTR2B / 5-HT2B Receptor Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
HTR2B (5-Hydroxytryptamine receptor 2B, serotonin receptor 2B) is a G-protein coupled receptor that binds serotonin as well as various ergot alkaloid derivatives and psychoactive substances. This receptor affects neural activity by regulating dopamine and serotonin release and uptake and by controlling extracellular levels of these neurotransmitters. HTR2B is involved in neuronal sensitization to tactile stimuli, behavioral regulation including impulsive behavior, and it may also play a role in the perception of pain. Mice lacking HTR2B have exhibited a schizophrenic-like phenotype and thus HTR2B is of interest in psychotic disorder neurobiology. It also has various cardiovascular roles; it is required for normal proliferation of embryonic cardiac myocytes and normal heart development and functions to protect cardiomyocytes against apoptosis. It is also necessary for normal osteoblast function and proliferation and for maintaining normal bone density. HTR2B agonists are of interest as possible treatments for migraines and chronic heart disease. In immunohistochemistry, HTR2B has highest cytoplasmic and membranous positivity in the cervix and endometrium. It is found in arcuate neurons in the brain, and it has positive staining in most other tissues. References: The Journal of Neuroscience. 28 (11): 2933–40, PMID: 18337424; Circulation Research. 104 (1): 1–3, PMID: 19118279; Mini Reviews in Medicinal Chemistry. 4 (3): 325–30, PMID: 15032678; Neuropsychopharmacology. 2015 Nov;40(12):2764-73, PMID: 25936642; J Exp Med. 2011 Jan 17;208(1):41-52,PMID: 21187319
Target
Human HTR2B / 5-HT2B Receptor
Synonyms
HTR2B | 5-HT 2B receptor | 5HT2B Receptor | 5-HT(2B) | 5-HT-2B | 5-HT2b receptor | 5-HT2B | Serotonin 2b receptor | Serotonin 5-HT-2b receptor | Serotonin receptor 2B
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Bat, Horse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 20 amino acid peptide from N-Terminus extracellular domain of human 5HT2B Receptor. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%); Marmoset, Bat (95%); Horse (90%); Dog, Panda (85%); Bovine, Rabbit (80%).
Epitope
N-Terminus
Specificity
Human 5HT2B Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (3 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About HTR2B / 5-HT2B Receptor
P41595 NM_000867 NP_000858.3

Validation

HTR2B / 5-HT2B Receptor Antibody - Brain, Amygdala neurons
Brain, Amygdala neurons
Brain, Amygdala neurons

HTR2B / 5-HT2B Receptor Antibody - Brain, Substantia Nigra
Brain, Substantia Nigra
Brain, Substantia Nigra

HTR2B / 5-HT2B Receptor Antibody - Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HTR2B / 5-HT2B Receptor Antibody - Anti-5HT2B Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT2B Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-5HT2B Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

HTR2B / 5-HT2B Receptor Antibody - Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-HTR1B / 5-HT2B Receptor antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ HTR2B / 5-HT2B Receptor Antibody (N-Terminus) for IHC LS-A1187 has an LSBio Rating of
Laboratory Validation Score (5)

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Requested From: United States
Date Requested: 7/16/2024