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Catalog Number Size Price
LS-A1631-50 50 µg (1 mg/ml) $460 
GPR48 / LGR4 Antibody - Breast, Carcinoma
GPR48 / LGR4 Antibody - Skin, Malignant Melanoma
GPR48 / LGR4 Antibody - Lung Adenocarcinoma
GPR48 / LGR4 Antibody - Anti-LGR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR48 / LGR4 Antibody - Anti-GPR48 / LGR4 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR48 / LGR4 Antibody - Anti-GPR48 / LGR4 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR48 / LGR4 Antibody - Lung, Adenocarcinoma
GPR48 / LGR4 Antibody - Breast, Carcinoma
GPR48 / LGR4 Antibody - Skin, Malignant Melanoma
GPR48 / LGR4 Antibody - Lung Adenocarcinoma
GPR48 / LGR4 Antibody - Anti-LGR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR48 / LGR4 Antibody - Anti-GPR48 / LGR4 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR48 / LGR4 Antibody - Anti-GPR48 / LGR4 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
GPR48 / LGR4 Antibody - Lung, Adenocarcinoma
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PathPlus™ Polyclonal Rabbit anti‑Human GPR48 / LGR4 Antibody (N‑Terminus, IHC) LS‑A1631

PathPlus™ Polyclonal Rabbit anti‑Human GPR48 / LGR4 Antibody (N‑Terminus, IHC) LS‑A1631

Antibody:
GPR48 / LGR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A1631-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
GPR48 / LGR4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human GPR48 / LGR4
Synonyms
LGR4 | G-protein coupled receptor 48 | G protein-coupled receptor 48 | GPR48
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Mouse, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from N-Terminus extracellular domain of human LGR4. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Orangutan, Marmoset, Mouse, Rabbit (94%); Rat, Elephant (88%); Dog, Bovine, Panda, Pig (81%).
Epitope
N-Terminus
Specificity
Human LGR4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (5 - 12 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About GPR48 / LGR4
Q9BXB1 NM_018490 NP_060960.2

Validation

GPR48 / LGR4 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

GPR48 / LGR4 Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

GPR48 / LGR4 Antibody - Lung Adenocarcinoma
Lung Adenocarcinoma
Lung Adenocarcinoma

GPR48 / LGR4 Antibody - Anti-LGR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LGR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-LGR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR48 / LGR4 Antibody - Anti-GPR48 / LGR4 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR48 / LGR4 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR48 / LGR4 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR48 / LGR4 Antibody - Anti-GPR48 / LGR4 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR48 / LGR4 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GPR48 / LGR4 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GPR48 / LGR4 Antibody - Lung, Adenocarcinoma
Lung, Adenocarcinoma
Lung, Adenocarcinoma

LSBio Ratings

PathPlus™ GPR48 / LGR4 Antibody (N-Terminus) for IHC LS-A1631 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/17/2021