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| Catalog Number | Size | Price |
|---|---|---|
| LS-A9666-50 | 50 µg (1 mg/ml) | $460 |
PathPlus™ Polyclonal Rabbit anti‑Human GABRA3 Antibody (C‑Terminus, IHC) LS‑A9666
PathPlus™ Polyclonal Rabbit anti‑Human GABRA3 Antibody (C‑Terminus, IHC) LS‑A9666
Antibody:
GABRA3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Rabbit
Format:
Unconjugated, Unmodified
Overview
Antibody:
GABRA3 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Rabbit
Format:
Unconjugated, Unmodified
Specifications
Description
GABRA3 (Gamma-aminobutyric acid receptor subunit alpha-3) is a receptor for GABA inhibitory neurotransmitters. In the brain, GABRA3 expression is correlated with reelin + neurons and to some extent with calbindin + pyramidal neurons. GABRA3 is thought to exert pro-inflammatory actions when dysregulated and this may be a contributing factor in the pathogenesis of Alzheimer’s disease and also Autism. GABRA3 is also aberrantly expressed in some breast cancers (it is normally exclusive to the brain), and is thought to contribute to invasion and metastasis. In immunohistochemistry, GABRA3 is primarily expressed in the cerebral cortex and throughout the central nervous system.
References: Front. Syst. Neurosci. 2019. DOI: 10.3389/fnsys.2019.00010; Nature Communications. 2016. Volume 7(10715); Journal of autism and developmental disorders. 2008. DOI: 10.1007/s10803-008-0646-
Target
Human GABRA3
Synonyms
GABRA3 | GABA(A) receptor, alpha 3 | GABA A receptor alpha 3
Host
Rabbit
Reactivity
Human, Monkey, Rabbit
(tested or 100% immunogen sequence identity)
Predicted
Mouse, Hamster (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 15 amino acid peptide from C-Terminus of human GABRA3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rabbit (100%); Mouse, Hamster (93%); Rat, Panda, Dog, Horse (87%); Bovine, Bat (80%).
Epitope
C-Terminus
Specificity
Human GABRA3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About GABRA3
Validation
Anti-GABRA3 antibody IHC of human brain, globus pallidus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-GABRA3 antibody IHC of human brain, globus pallidus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ GABRA3 Antibody (C-Terminus) for IHC LS-A9666 has an LSBio Rating of
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (0)
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Hamster, Horse, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Rabbit
Applications:
IHC, IHC - Paraffin
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Western blot
Reactivity:
Pig
Range:
0.156-10 ng/ml
Reactivity:
Human
Range:
0.78-50 ng/ml
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/23/2024
Date Requested: 4/23/2024
