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Catalog Number Size Price
LS-A4482-50 50 µg (1 mg/ml) $440 
FZD6 / Frizzled 6 Antibody - Skin, Malignant Melanoma
FZD6 / Frizzled 6 Antibody - Lung, non small-cell carcinoma
FZD6 / Frizzled 6 Antibody - Ovary, carcinoma
FZD6 / Frizzled 6 Antibody - Brain, Glioblastoma
FZD6 / Frizzled 6 Antibody - Anti-FZD6 / Frizzled 6 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD6 / Frizzled 6 Antibody - Skin, Malignant Melanoma
FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with Frizzled-6.
FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
FZD6 / Frizzled 6 Antibody - Skin, Malignant Melanoma
FZD6 / Frizzled 6 Antibody - Lung, non small-cell carcinoma
FZD6 / Frizzled 6 Antibody - Ovary, carcinoma
FZD6 / Frizzled 6 Antibody - Brain, Glioblastoma
FZD6 / Frizzled 6 Antibody - Anti-FZD6 / Frizzled 6 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD6 / Frizzled 6 Antibody - Skin, Malignant Melanoma
FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with Frizzled-6.
FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
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PathPlus™ Polyclonal Rabbit anti‑Human FZD6 / Frizzled 6 Antibody (N‑Terminus, IHC) LS‑A4482

PathPlus™ Polyclonal Rabbit anti‑Human FZD6 / Frizzled 6 Antibody (N‑Terminus, IHC) LS‑A4482

Antibody:
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$440
LS-A4482-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
FZD6 / Frizzled 6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human FZD6 / Frizzled 6
Synonyms
FZD6 | Frizzled family receptor 6 | FZ-6 | HFZ6 | Frizzled 6 | Frizzled-6 | Frizzled homolog 6 | FZ6 | NDNC10
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Predicted
Mouse, Bovine, Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from N-Terminus extracellular domain of human Frizzled-6. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset (100%); Mouse, Panda, Bovine, Dog, Horse, Rabbit, Pig (94%); Rat, Opossum, Turkey, Chicken (88%); Elephant, Bat, Lizard (81%).
Epitope
N-Terminus
Specificity
Human Frizzled-6. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except FZD3 (50%).
Applications
  • IHC - Paraffin (10 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About FZD6 / Frizzled 6
O60353 NM_003506 NP_003497.2

Validation

FZD6 / Frizzled 6 Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

FZD6 / Frizzled 6 Antibody - Lung, non small-cell carcinoma
Lung, non small-cell carcinoma
Lung, non small-cell carcinoma

FZD6 / Frizzled 6 Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

FZD6 / Frizzled 6 Antibody - Brain, Glioblastoma
Brain, Glioblastoma
Brain, Glioblastoma

FZD6 / Frizzled 6 Antibody - Anti-FZD6 / Frizzled 6 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD6 / Frizzled 6 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD6 / Frizzled 6 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FZD6 / Frizzled 6 Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Frizzled-6 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-Frizzled-6 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with Frizzled-6.
Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with Frizzled-6.
Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of HEK293 human embryonic kidney cells transfected with Frizzled-6.

FZD6 / Frizzled 6 Antibody - Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.
Anti-Frizzled-6 antibody immunocytochemistry (ICC) staining of untransfected HEK293 human embryonic kidney cells.

LSBio Ratings

PathPlus™ FZD6 / Frizzled 6 Antibody (N-Terminus) for IHC LS-A4482 has an LSBio Rating of
Laboratory Validation Score (5)

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/28/2021