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Catalog Number Size Price
LS-A4284-50 50 µg (1 mg/ml) $460 
FZD5 / Frizzled 5 Antibody - Brain, Glioblastoma
FZD5 / Frizzled 5 Antibody - Breast, Carcinoma
FZD5 / Frizzled 5 Antibody - Ovary, carcinoma
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Brain, Glioblastoma
FZD5 / Frizzled 5 Antibody - Breast, Carcinoma
FZD5 / Frizzled 5 Antibody - Ovary, carcinoma
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human FZD5 / Frizzled 5 Antibody (Cytoplasmic Domain, IHC) LS‑A4284

PathPlus™ Polyclonal Rabbit anti‑Human FZD5 / Frizzled 5 Antibody (Cytoplasmic Domain, IHC) LS‑A4284

Antibody:
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A4284-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
FZD5 / Frizzled 5 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Interacts specifically with Wnt5A to induce the beta-catenin pathway. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human FZD5 / Frizzled 5
Synonyms
FZD5 | C2orf31 | DKFZP434E2135 | Frizzled family receptor 5 | Fz5 | Fzd-5 | FzE5 | Frizzled 5 | Frizzled-5 | Wnt receptor | Fz-5 | HFZ5
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Mouse, Rat, Bovine, Dog, Pig, Rabbit (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human FZD5 / Frizzled 5. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Mouse, Rat, Elephant, Dog, Bovine, Rabbit, Pig (94%); Marmoset (88%); Hamster (81%).
Epitope
Cytoplasmic Domain
Specificity
Human FZD5 / Frizzled 5. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ART5 (44%).
Applications
  • IHC
  • IHC - Paraffin (24 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About FZD5 / Frizzled 5
Q13467 NM_003468 NP_003459.2

Validation

FZD5 / Frizzled 5 Antibody - Brain, Glioblastoma
Brain, Glioblastoma
Brain, Glioblastoma

FZD5 / Frizzled 5 Antibody - Breast, Carcinoma
Breast, Carcinoma
Breast, Carcinoma

FZD5 / Frizzled 5 Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

FZD5 / Frizzled 5 Antibody - Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-FZD5 / Frizzled 5 antibody IHC of human synovium, rheumatoid arthritis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ FZD5 / Frizzled 5 Antibody (Cytoplasmic Domain) for IHC LS-A4284 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

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Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/16/2021