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Catalog Number Size Price
LS-A5745-50 50 µg (1 mg/ml) $460 
EAR2 / NR2F6 Antibody - Brain, Glioblastoma
EAR2 / NR2F6 Antibody - Ovary, carcinoma
EAR2 / NR2F6 Antibody - Skin, Malignant Melanoma
EAR2 / NR2F6 Antibody - Anti-EAR2 / NR2F6 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EAR2 / NR2F6 Antibody - Anti-NR2F6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EAR2 / NR2F6 Antibody - Brain, Glioblastoma
EAR2 / NR2F6 Antibody - Ovary, carcinoma
EAR2 / NR2F6 Antibody - Skin, Malignant Melanoma
EAR2 / NR2F6 Antibody - Anti-EAR2 / NR2F6 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
EAR2 / NR2F6 Antibody - Anti-NR2F6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human EAR2 / NR2F6 Antibody (N‑Terminus, IHC) LS‑A5745

PathPlus™ Polyclonal Rabbit anti‑Human EAR2 / NR2F6 Antibody (N‑Terminus, IHC) LS‑A5745

Antibody:
EAR2 / NR2F6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A5745-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
EAR2 / NR2F6 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human EAR2 / NR2F6
Synonyms
NR2F6 | Erba related 2 | ERBAL2 | EAR-2 | EAR2 | ERBA-related gene-2 | V-erbA-related protein 2
Host
Rabbit
Reactivity
Human, Monkey (tested or 100% immunogen sequence identity)
Predicted
Mouse (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 17 amino acid peptide near N-Terminus of human NR2F6. Percent identity with other species by BLAST analysis: Human, Monkey (100%); Mouse (94%); Dog (88%); Opossum (82%).
Epitope
N-Terminus
Specificity
Human NR2F6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (4 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About EAR2 / NR2F6
P10588 NM_005234 AAH02669.3

Validation

EAR2 / NR2F6 Antibody - Brain, Glioblastoma
Brain, Glioblastoma
Brain, Glioblastoma

EAR2 / NR2F6 Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

EAR2 / NR2F6 Antibody - Skin, Malignant Melanoma
Skin, Malignant Melanoma
Skin, Malignant Melanoma

EAR2 / NR2F6 Antibody - Anti-EAR2 / NR2F6 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EAR2 / NR2F6 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-EAR2 / NR2F6 antibody IHC of human Lymph Node, Non-Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

EAR2 / NR2F6 Antibody - Anti-NR2F6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR2F6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR2F6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ EAR2 / NR2F6 Antibody (N-Terminus) for IHC LS-A5745 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/16/2021