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Catalog Number Size Price
LS-A6785-50 50 µg (1 mg/ml) $460 
DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
DUSP26 / MKP8 Antibody - Brain, substantia nigra
DUSP26 / MKP8 Antibody - Brain, Alzheimer's disease, neurofibrillary tangle
DUSP26 / MKP8 Antibody - Anti-DUSP26 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
DUSP26 / MKP8 Antibody - Brain, substantia nigra
DUSP26 / MKP8 Antibody - Brain, Alzheimer's disease, neurofibrillary tangle
DUSP26 / MKP8 Antibody - Anti-DUSP26 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PathPlus™ Polyclonal Rabbit anti‑Human DUSP26 / MKP8 Antibody (Internal, IHC) LS‑A6785

PathPlus™ Polyclonal Rabbit anti‑Human DUSP26 / MKP8 Antibody (Internal, IHC) LS‑A6785

Antibody:
DUSP26 / MKP8 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Hamster, Horse, Pig, Rabbit, Chicken
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$460
LS-A6785-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
DUSP26 / MKP8 Rabbit anti-Human Polyclonal (Internal) Antibody
Application:
IHC, IHC-P
Reactivity:
Human, Monkey, Mouse, Rat, Bat, Bovine, Hamster, Horse, Pig, Rabbit, Chicken
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Dual specificity phosphatase 26 (DUSP26, MKP8) is a tyrosine phosphatase that functions to inactivate MAPK1 and MAPK3, which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. DUSP26 inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. DUSP26 can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK). It is thought to function variably as both a tumor suppressor and an oncogene in glioblastoma, and separately modulates neuronal proliferation. DUSP26 has been found to be upregulated in the hippocampus of Alzheimer's patients. In immunohistochemistry, DUSP26 has highest cytoplasmic positivity in neurons throughout the central nervous system and in skeletal muscle, and is also found at moderate levels in the lung, heart muscle, breast tissue, reproductive tissues, the urinary bladder, tonsils, and at lower levels in a few other tissues. References: J Neurochem. 2016 Jun;137(5):770-81. doi: 10.1111/jnc.13597. Epub 2016 Mar 17, PMID: 26924229;
Target
Human DUSP26 / MKP8
Synonyms
DUSP26 | DSP-4 | NATA1 | SKRP3 | MAP kinase phosphatase 8 | MKP-8 | DUSP24 | LDP-4 | LDP4 | MKP8
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Rat, Bat, Bovine, Hamster, Horse, Pig, Rabbit, Chicken (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 14 amino acid peptide from internal region of human DUSP26. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Bovine, Horse, Rabbit, Pig, Turkey, Chicken (100%); Opossum, Platypus (93%); Stickleback, Pufferfish (86%).
Epitope
Internal
Specificity
Human DUSP26. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (7 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About DUSP26 / MKP8
Q9BV47 NM_024025 NP_076930.1

Validation

DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MKP-8 / DUSP26 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MKP-8 / DUSP26 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

DUSP26 / MKP8 Antibody - Brain, substantia nigra
Brain, substantia nigra
Brain, substantia nigra

DUSP26 / MKP8 Antibody - Brain, Alzheimer's disease, neurofibrillary tangle
Brain, Alzheimer's disease, neurofibrillary tangle
Brain, Alzheimer's disease, neurofibrillary tangle

DUSP26 / MKP8 Antibody - Anti-DUSP26 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-DUSP26 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-DUSP26 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MKP-8 / DUSP26 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MKP-8 / DUSP26 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

DUSP26 / MKP8 Antibody - Anti-MKP-8 / DUSP26 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MKP-8 / DUSP26 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-MKP-8 / DUSP26 antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

LSBio Ratings

PathPlus™ DUSP26 / MKP8 Antibody (Internal) for IHC LS-A6785 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/17/2021