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CTSD / Cathepsin D

cathepsin D

CTSD / Cathepsin D is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. In Chinese hamster the protein Cathepsin D is encoded by the gene H671_3g9701 (Uniprot G3I4W7).

Gene Name: cathepsin D
Family/Subfamily: Protease , Aspartic A1
Synonyms: CTSD, CPSD, CLN10, Lysosomal aspartyl peptidase, Lysosomal aspartyl protease, ProCathepsin D, CatD, Cathepsin D
Target Sequences: NM_001909 NP_001900.1 P07339

Publications (2)

1
Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aß and tau pathology. Perez SE, He B, Nadeem M, Wuu J, Ginsberg SD, Ikonomovic MD, Mufson EJ. Journal of neuropathology and experimental neurology. 2015 74:345-58. (WB; Human) [Full Text Article] [PubMed:25756588] [PMC:PMC4366294]
2
Autophagy-mediated degradation of nuclear envelope proteins during oncogene-induced senescence. Lenain C, Gusyatiner O, Douma S, van den Broek B, Peeper DS. Carcinogenesis. 2015 November;36:1263-1274. [Full Text Article] [PubMed:26354777]

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CTSD / Cathepsin D Antibody - Anti-CTSD / Cathepsin D antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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CTSD / Cathepsin D Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$440
CTSD / Cathepsin D Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Neuroscience
CTSD / Cathepsin D Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
CTSD / Cathepsin D Antibody - Anti-Cathepsin D antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CTSD / Cathepsin D Mouse anti-Human Monoclonal (3F12-1B9) Antibody
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
CTSD / Cathepsin D Antibody - Immunohistochemical of paraffin-embedded H.breast carcinoma section using CTSD. Antibody was diluted at 1:25 dilution. A peroxidase-conjugated goat anti-rabbit IgG at 1:400 dilution was used as the secondary antibody, followed by DAB staining.
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CTSD / Cathepsin D ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Mouse
2.74 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$990
CTSD / Cathepsin D ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$856
CTSD / Cathepsin D Antibody - Anti-Cathepsin D antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
250 µl/$495
CTSD / Cathepsin D Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CTSD / Cathepsin D Antibody - IHC testing of FFPE human renal cell carcinoma with Cathepsin D antibody (clone CTSD/2781). HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.
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CTSD / Cathepsin D Mouse anti-Human Monoclonal (Azide-free, BSA-free) (CTSD/2781) Antibody
Human
IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$331
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E. coli
His
40.9 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
CTSD / Cathepsin D ELISA Kit
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Sandwich
96-Well Microplate
Human
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$718
CTSD / Cathepsin D Antibody - Immunohistochemistry of polyclonal antibody to C1SD (1:200) on paraformaldehyde-fixed paraffin-embedded mouse lung.
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CTSD / Cathepsin D Goat anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
600 µg/$422
CTSD / Cathepsin D Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
CTSD / Cathepsin D Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Pig, Human
IHC-P, WB
Unconjugated
50 µl/$460
CTSD / Cathepsin D Antibody - IHC-P: Cathepsin D antibody testing of mouse kidney tissue
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CTSD / Cathepsin D Rabbit anti-Mouse Polyclonal (aa65-410) Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
100 µg/$575
CTSD / Cathepsin D Antibody
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CTSD / Cathepsin D Mouse anti-Human Monoclonal Antibody
Human
ELISA, WB
Unconjugated
100 µl/$445
CTSD / Cathepsin D Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
CTSD / Cathepsin D Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
CTSD / Cathepsin D Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Neuroscience
Cancer
CTSD / Cathepsin D Rabbit anti-Human Polyclonal (aa72-292) Antibody
Human
IHC-P, WB
Unconjugated
50 µl/$460
CTSD / Cathepsin D Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal (APC) Antibody
Mouse, Human
WB
APC Conjugated
100 µl/$937
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$688
CTSD / Cathepsin D Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CTSD / Cathepsin D Mouse anti-Human Monoclonal (Sepharose) (CP-D13) Antibody
Human
IP
Sepharose Conjugated
100 µg/$399
CTSD / Cathepsin D Antibody - Immunohistochemistry of paraffin-embedded human liver cancer tissue.
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CTSD / Cathepsin D Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using CTSD antibody at dilution of 1:100 (40x lens).
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CTSD / Cathepsin D Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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CTSD / Cathepsin D Mouse anti-Human Monoclonal Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µg/$564
Viewing 1-25 of 207 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).