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Catalog Number Size Price
LS-B16239-100 100 µg (200 µg/ml) $485 
CGB / hCG Beta Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
CGB / hCG Beta Antibody - SDS-PAGE Analysis Purified hCG beta Mouse Recombinant Monoclonal Antibody (rHCGb/54). Confirmation of Purity and Integrity of Antibody.
CGB / hCG Beta Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
CGB / hCG Beta Antibody - SDS-PAGE Analysis Purified hCG beta Mouse Recombinant Monoclonal Antibody (rHCGb/54). Confirmation of Purity and Integrity of Antibody.
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PathPlus™ Recombinant Monoclonal Mouse anti‑Human CGB / hCG Beta Antibody (clone rHCGb/54, IHC) LS‑B16239

PathPlus™ Recombinant Monoclonal Mouse anti‑Human CGB / hCG Beta Antibody (clone rHCGb/54, IHC) LS‑B16239

Note: This antibody replaces LS-C751095
Antibody:
CGB / hCG Beta Mouse anti-Human Recombinant Monoclonal (rHCGb/54) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$485
LS-B16239-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
CGB / hCG Beta Mouse anti-Human Recombinant Monoclonal (rHCGb/54) Antibody
Application:
IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
Beta Human Chorionic Gonadotrophin (beta hCG, CGB) is a human glycoprotein hormone expressed by placental trophoblasts that stimulate ovaries to synthesize steroids needed to maintain pregnancy. HCG is a useful marker for detecting pregnancy, as well as identifying choriocarcinomas or tumors of syncytiotrophoblasts. Serum levels of HCG are also used to stage gestational trophoblastic tumors or germ cell tumors. HCG is positive in placental trophoblasts, germ cell tumors, choriocarcinomas, granulosa cell tumors, hydatidiform mole, invasive colorectal cancer, serous effusions with reactive mesothelium, and testicular seminomas with syncytiotrophoblasts. References: Mod Pathol 2004;17:701, PMID: 15001996; Cell Physiol Biochem. 2018;45(1):237-249, PMID: 29357321
Target
Human CGB / hCG Beta
Synonyms
CGB | CGB3 | CG-beta | HCGB | hCG Beta
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Recombinant Monoclonal
Clone
rHCGb/54
Conjugations
Unconjugated
Purification
Protein A/G purified
Modifications
Unmodified. Also available Azide-free, Carrier-free.
Immunogen
Recombinant full-length human hCG beta protein. Antigen Molecular Weight: 22 kDa
Specificity
This MAb reacts with a protein of 22 kDa , identified as beta sub-unit of HCG. It does not cross react with the alpha sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.
Applications
  • IHC - Paraffin (1:50)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistology (Formalin-fixed - 0.5-1 ug/ml; 30 min RT - Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes.) Optimal dilution for a specific application should be determined.
Presentation
10 mM PBS, 0.05% BSA, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C for up to 2 years.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About CGB / hCG Beta
Q6NT52 NM_000737 NP_000728.1

Validation

CGB / hCG Beta Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)

LSBio Ratings

PathPlus™ CGB / hCG Beta Antibody (clone rHCGb/54) for IHC LS-B16239 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 9/27/2021