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| Catalog Number | Size | Price |
|---|---|---|
| LS-B14248-300 | 300 µg (3 mg/ml) | $440 |
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PathPlus™ Polyclonal Goat anti‑Human CD45 / LCA Antibody (C‑Terminus, IHC, WB) LS‑B14248
PathPlus™ Polyclonal Goat anti‑Human CD45 / LCA Antibody (C‑Terminus, IHC, WB) LS‑B14248
Note: This antibody replaces LS-C204257
Antibody:
CD45 / LCA Goat anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Monkey, Mouse, Rat, Dog
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
CD45 / LCA Goat anti-Human Polyclonal (C-Terminus) Antibody
Application:
IHC, IHC-P, WB
Reactivity:
Human, Monkey, Mouse, Rat, Dog
Format:
Unconjugated, Unmodified
Specifications
Description
CD45 (LCA, PTPRC) is a type 1 transmembrane protein tyrosine phosphatase that is a marker for leukocytes. It is expressed on almost all hematopoietic cells (B and T-lymphocytes, granulocytes, monocytes, mast cells, dendritic cells, and macrophages). It is positive in many hematolymphoid neoplasms and may assist in the classification of lymphomas and leukemias. It is negative in mature erythrocytes, platelets, plasma cells, and mature megakaryocytes. Defects in PTPRC are one cause of severe combined immunodeficiency syndrome characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
References: Hermiston et al. Annual review of immunology 21.1 (2003): 107-137, DOI: 10.1146/annurev.immunol.21.120601.140946;Am J Clin Pathol 1998;110:797, PMID: 9844593
Target
Human CD45 / LCA
Synonyms
PTPRC | B220 | CD45R | CD45 | gp180 | Leukocyte common antigen | L-CA | Leucocyte common antigen | LY5 | T200 | T200 glycoprotein | T200 leukocyte common antigen | CD45 antigen | LCA
Host
Goat
Reactivity
Human, Monkey, Mouse, Rat, Dog
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Purified recombinant peptide derived from within residues 1260 aa to the C-Terminus of human CD45 produced in E. coli.
Epitope
C-Terminus
Specificity
Using Jurkat cell lysate detects a band 180-220 kDa by Western blot.
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- Western blot (1:500 - 1:2000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.05% Sodium Azide, 20% Glycerol
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About CD45 / LCA
Validation
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
See More About...
LSBio Ratings
PathPlus™ CD45 / LCA Antibody (C-Terminus) for IHC, WB/Western LS-B14248 has an LSBio Rating of
Publications (4)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (1)
Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers10<sup> Center for Comprehensive Developmental Care (CDeCLMU), Member of the German Center for Lung Research (DZL), Hospital of the Ludwig-Maximilians University (LMU), CPC-M bioArchive, Munich, Germany12<sup> Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Christoph H Mayr, Lukas M Simon, Gabriela Leuschner , Meshal Ansari , Janine Schniering , Philipp E Geyer, Ilias Angelidis, Maximilian Strunz, Pawandeep Singh, Nikolaus Kneidinger, Frank Reichenberger, Edith Silbernagel, Stephan Böhm, Heiko Adler, Michael Lindner , Britta Maurer, Anne Hilgendorff, Antje Prasse, Jürgen Behr , Matthias Mann, Oliver Eickelberg, Fabian J Theis, Herbert B Schiller. EMBO molecular medicine. 2021 Apr;13:e12871.
Customer Reviews (0)
Featured Products
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human
Applications:
IHC - Paraffin, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry
Species:
Human
Applications:
IHC - Paraffin, Western blot
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/17/2024
Date Requested: 4/17/2024
